{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARHGEF26‐AS1, a long non‐coding RNA, has emerged as a multifunctional regulator in diverse pathological contexts, with a prominent role in tumor biology. In esophageal squamous cell carcinoma, ARHGEF26‐AS1 functions as a competing endogenous RNA that sponges miR‐372–3p, thereby de‐repressing ADAM23 expression; this mechanism leads to enhanced ferroptosis and is associated with decreased cell proliferation and migration (a."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon cancer, ARHGEF26‐AS1 is incorporated into competing endogenous RNA networks, and its dysregulated expression correlates with patient prognosis, suggesting its utility as a prognostic biomarker (b."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in glioma and low‐grade glioma, ARHGEF26‐AS1 is part of autophagy‐ and ferroptosis‐related prognostic signatures that are indicative of tumor progression and treatment response (c."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma, ARHGEF26‐AS1 is featured within risk signatures based on m6A‐related and ferroptosis/iron metabolism–related long non‐coding RNAs, further highlighting its potential as a prognostic and therapeutic target (d."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Beyond oncology, altered levels of ARHGEF26‐AS1 have also been identified among differentially expressed transcripts in pulpitis, implying a broader regulatory role in inflammatory conditions (e."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore that ARHGEF26‐AS1 modulates gene expression via ceRNA interactions, influencing key cellular processes such as ferroptosis, proliferation, migration, and autophagy. Its consistent inclusion in prognostic signatures across different diseases indicates that ARHGEF26‐AS1 may serve both as a valuable biomarker and as a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Chen, Jun Zhao, Jing-Ni Liu, et al. 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