{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of stomach adenocarcinoma, ARHGEF38‐IT1 was identified as one of nine genes in a prognostic signature that is strongly associated with cancer stem cell characteristics, overall survival, and clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The inclusion of ARHGEF38‐IT1 in this multi‐gene model suggests that its expression may be linked to the regulation of cancer stemness, influencing key tumor cell features such as infinite proliferation, self‐renewal, and dynamic interactions within the tumor immune microenvironment. Moreover, correlations observed between the gene signature (including ARHGEF38‐IT1) with factors such as tumor mutation burden, copy number variations, and immune cell infiltration underscore its potential role in modulating tumor plasticity and the overall tumorigenic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zaisheng Ye, Miao Zheng, Yi Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics Analysis Reveals an Association Between Cancer Cell Stemness, Gene Mutations, and the Immune Microenvironment in Stomach Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.595477"}], "href": "https://doi.org/10.3389/fgene.2020.595477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33362856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33362856"}]}]}]}