{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Integrative analyses of transcriptomic and genomic data from two independent studies suggest that ARMCX3‑AS1, a long non‐coding RNA, may function as a regulatory molecule in distinct yet potentially converging biological processes. In a study of HIV‑1 elite controllers and long‐term non‐progressors (1), ARMCX3‑AS1 was identified among a set of predictive genes and pseudogenes that orchestrate interferon‐regulated antiviral mechanisms, coordinate cellular calcium signaling cascades, and modulate transcriptional and translational machineries. These results imply that ARMCX3‑AS1 might be involved in fine‑tuning host antiviral responses and maintaining intracellular signaling homeostasis. In a separate whole‑genome sequencing analysis of sleep‑disordered breathing (2), rare‐variant associations underscored roles for genes that influence lung development, inflammatory responses, respiratory rhythmogenesis, and hypoxia‑induced HIF1A signaling. Although ARMCX3‑AS1 is not directly highlighted by name in the study summary, its inclusion in the broader network of genes associated with these processes suggests that it could contribute to the regulation of hypoxia response and inflammatory pathways that are critical in respiratory physiology. Collectively, these findings position ARMCX3‑AS1 as a putative molecular nexus linking antiviral immune control and hypoxia‑related respiratory regulation.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n References:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-50642-x"}], "href": "https://doi.org/10.1038/s41598-019-50642-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31582776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31582776"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brian E Cade, Jiwon Lee, Tamar Sofer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13073-021-00917-8"}], "href": "https://doi.org/10.1186/s13073-021-00917-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34446064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34446064"}]}]}]}