{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARNTL2‐AS1 is a long noncoding RNA transcribed antisense to the ARNTL2 gene that appears to play a regulatory role in modulating gene expression. Although the genome‐wide association study of suicide attempt severity (Abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "identified a significant association near the LDHB gene, it did not directly implicate ARNTL2‐AS1. However, evidence from parallel investigations of long noncoding RNAs indicates that ARNTL2‐AS1 may influence pathways relevant to circadian regulation, metabolic homeostasis, and neurodevelopment, processes that are increasingly recognized as contributing factors to psychiatric outcomes and behavioral dysregulation. In this context, ARNTL2‐AS1 is hypothesized to modulate transcriptional networks in neural tissues, potentially affecting vulnerability to mood disorders and suicidal behaviors. Further research is warranted to delineate the functional consequences of ARNTL2‐AS1 expression and its intersection with the molecular mechanisms underlying the risk of suicide attempts, as highlighted by the genetic signals observed in contemporary GWAS analyses (1).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel F Levey, Renato Polimanti, Zhongshan Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic associations with suicide attempt severity and genetic overlap with major depression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-018-0340-2"}], "href": "https://doi.org/10.1038/s41398-018-0340-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30655502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30655502"}]}]}]}