{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARPC1B is an essential subunit of the Arp2/3 complex that plays a critical role in regulating actin filament branching and dynamics. Arp2/3 complexes containing the ARPC1B isoform are more efficient at promoting actin assembly and form branched networks that are more resistant to disassembly than those containing alternative isoforms, underscoring its importance in actin nucleation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hematopoietic cells, particularly in platelets and immune cells, ARPC1B is crucial for maintaining proper cytoskeletal organization. Deficiency of ARPC1B in patients leads to microthrombocytopenia, aberrant platelet spreading, and a constellation of immune dysregulation symptoms, highlighting its vital role in blood cell function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its contributions to actin dynamics, ARPC1B has been implicated in cell cycle regulation. It facilitates centrosomal homeostasis by promoting Aurora A kinase activation at the centrosome—a process that is essential for proper centrosome maturation and entry into mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, altered ARPC1B expression appears to influence tumor cell migration and invasion. Reduced expression has been linked with lymph node metastasis and advanced tumor staging in oral squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while increased ARPC1B levels have been associated with prostate cancer progression and invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, ARPC1B functions in vascular endothelial cells by mediating actin remodeling necessary for cell migration and re‐endothelialization, acting downstream of regulators such as EVA1A to promote tissue repair and maintain vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish ARPC1B as a versatile regulator of actin cytoskeletal remodeling that is pivotal for proper mitotic progression, immunological integrity, and controlling the migratory and invasive properties of cancer cells.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jasmine V G Abella, Chiara Galloni, Julien Pernier, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14816"}], "href": "https://doi.org/10.1038/ncomms14816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28368018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28368018"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andreja N Kopitar, Gašper Markelj, Miha Oražem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flow Cytometric Determination of Actin Polymerization in Peripheral Blood Leukocytes Effectively Discriminate Patients With Homozygous Mutation in ARPC1B From Asymptomatic Carriers and Normal Controls."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.01632"}], "href": "https://doi.org/10.3389/fimmu.2019.01632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31379835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31379835"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Immacolata Brigida, Matteo Zoccolillo, Maria Pia Cicalese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-cell defects in patients with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ARPC1B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " germline mutations account for combined immunodeficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2018-07-863431"}], "href": "https://doi.org/10.1182/blood-2018-07-863431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30254128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30254128"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Poonam R Molli, Da-Qiang Li, Rozita Bagheri-Yarmand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200908050"}], "href": "https://doi.org/10.1083/jcb.200908050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20603326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20603326"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lukman Bin Md Auzair, Vui King Vincent-Chong, Wan Maria Nabillah Ghani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Arch Otorhinolaryngol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00405-015-3703-9"}], "href": "https://doi.org/10.1007/s00405-015-3703-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26138391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26138391"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tianqi Liu, Chen Zhu, Xin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncoimmunology (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/2162402X.2022.2031499"}], "href": "https://doi.org/10.1080/2162402X.2022.2031499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35111386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35111386"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yaser Gamallat, Hend Zaaluk, Ealia Khosh Kish, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition Decreases Cell Invasion and Migration In Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23031476"}], "href": "https://doi.org/10.3390/ijms23031476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35163398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35163398"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jingxuan Li, Yingyu Chen, Jianing Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvaa011"}], "href": "https://doi.org/10.1093/cvr/cvaa011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31977009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31977009"}]}]}]}