ARRB2 Gene

Name	arrestin, beta 2
Description	Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Beta‐arrestin 2 (ARRB2) is a multifaceted adaptor protein that – beyond its classic role in desensitizing and internalizing activated G protein–coupled receptors – serves as a central scaffold to coordinate diverse, G protein–independent signaling events. ARRB2 directly couples to a variety of receptors including the β<sub>2</sub>–adrenergic, angiotensin, TGF‐β type III, and Smoothened receptors to mediate delayed and sustained activation of mitogen–activated protein kinases such as ERK1/2, thereby modulating cell proliferation, chemotaxis, and receptor trafficking ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "]. In immune and inflammatory contexts, ARRB2 participates in the blockade of pro–inflammatory nuclear factor–κB signaling – for example, by strengthening the association between IκBα and other regulatory proteins – and by attenuating TRAF6 autoubiquitination, which limits cytokine production ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]. Furthermore, ARRB2 scaffolds critical signaling complexes that regulate metabolic and neurobehavioral functions; it modulates Akt and Src signaling to influence insulin sensitivity and mood, and its recruitment by dopamine and opioid receptors shapes neurotransmission and behavioral responses ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "]. In the regulation of cell migration, ARRB2 enhances chemotactic responses via CXCR4 by promoting p38 MAPK and ERK activation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "]. Structural studies reveal that ARRB2 recognizes specific phosphorylation “barcodes” on receptor tails, thereby determining distinct downstream functional outcomes – including receptor ubiquitination via recruitment of Nedd4 ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "]. Moreover, biased agonism at receptors such as the kappa opioid and serotonin 2A receptors hinges on selective ARRB2 engagement, which differentially regulates outcomes such as antinociception versus dysphoria or distinct behavioral responses ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "]. Finally, evidence from cardiomyocytes indicates that ARRB2 contributes to non–G protein–mediated inotropic and lusitropic responses, while its conformational versatility – as revealed by biosensor studies – underpins its capacity to direct multiple downstream effector pathways ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "]. Genetic association studies further implicate ARRB2 in neurodevelopmental disorders, underscoring its broad physiological relevance ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "]. Collectively, these studies highlight ARRB2’s central role in fine–tuning receptor signaling, presenting it as a promising target for therapeutic interventions across diverse pathological states.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sudha K Shenoy, Matthew T Drake, Christopher D Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506576200"}], "href": "https://doi.org/10.1074/jbc.M506576200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16280323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16280323"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huijun Wei, Seungkirl Ahn, Sudha K Shenoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1834556100"}], "href": "https://doi.org/10.1073/pnas.1834556100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12949261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12949261"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Diane Gesty-Palmer, Minyong Chen, Eric Reiter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513380200"}], "href": "https://doi.org/10.1074/jbc.M513380200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16492667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16492667"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Chen, Xiu-Rong Ren, Christopher D Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1104135"}], "href": "https://doi.org/10.1126/science.1104135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15618519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15618519"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Thijs W H Pols, Mitsunori Nomura, Taoufiq Harach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2011.11.006"}], "href": "https://doi.org/10.1016/j.cmet.2011.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22152303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22152303"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yaya Wang, Yawei Tang, Lin Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1294"}], "href": "https://doi.org/10.1038/ni1294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16378096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16378096"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jean-Martin Beaulieu, Sébastien Marion, Ramona M Rodriguiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A beta-arrestin 2 signaling complex mediates lithium action on behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.11.041"}], "href": "https://doi.org/10.1016/j.cell.2007.11.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18191226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18191226"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bing Luan, Jian Zhao, Haiya Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07617"}], "href": "https://doi.org/10.1038/nature07617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19122674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19122674"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nora D Volkow, Dardo Tomasi, Gene-Jack Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0045-12.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.0045-12.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22573693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22573693"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yue Sun, Zhijie Cheng, Lan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M207294200"}], "href": "https://doi.org/10.1074/jbc.M207294200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12370187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12370187"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "X Edward Zhou, Yuanzheng He, Parker W de Waal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2017.07.002"}], "href": "https://doi.org/10.1016/j.cell.2017.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28753425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28753425"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sudha K Shenoy, Kunhong Xiao, Vidya Venkataramanan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709668200"}], "href": "https://doi.org/10.1074/jbc.M709668200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18544533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18544533"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tarsis F Brust, Jenny Morgenweck, Susy A Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aai8441"}], "href": "https://doi.org/10.1126/scisignal.aai8441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27899527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27899527"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cullen L Schmid, Kirsten M Raehal, Laura M Bohn "}, {"type": "b", "children": [{"type": "t", "text": "Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0708862105"}], "href": "https://doi.org/10.1073/pnas.0708862105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18195357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18195357"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Keshava Rajagopal, Erin J Whalen, Jonathan D Violin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1083195"}], "href": "https://doi.org/10.1126/science.1083195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12958365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12958365"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "K Brookes, X Xu, W Chen, et al. 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Synonyms	BARR2, ARB2, ARR2
Proteins	ARRB2_HUMAN
NCBI Gene ID	409
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARRB2 has 10,671 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for ARRB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARRB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARRB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARRB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARRB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARRB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARRB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARRB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARRB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARRB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARRB2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARRB2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARRB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARRB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARRB2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARRB2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARRB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARRB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARRB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ARRB2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARRB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARRB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARRB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARRB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARRB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ARRB2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARRB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARRB2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARRB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARRB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ARRB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARRB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARRB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARRB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARRB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARRB2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARRB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARRB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARRB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ARRB2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ARRB2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARRB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.