{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In recent pharmacogenomic investigations, the long noncoding RNA ARRDC3‐AS1 has emerged as a candidate regulator of serum potassium homeostasis in the context of antihypertensive therapy. Analyses of SNP‐by‐drug interactions among patients treated with ACE inhibitors, ARBs, or thiazide diuretics have identified significant genetic variants that may lie within or near the ARRDC3‐AS1 locus, suggesting that this antisense RNA could modulate gene expression pathways involved in potassium regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Such findings indicate that ARRDC3‐AS1 might influence the body’s response to these medications by affecting electrolyte balance, and therefore, it holds potential as a marker for individualized antihypertensive treatment strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marguerite R Irvin, Colleen M Sitlani, Raymond Noordam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41397-018-0021-9"}], "href": "https://doi.org/10.1038/s41397-018-0021-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29855607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29855607"}]}]}]}