| HGNC Family | Sulfatases (ARS) |
| Name | arylsulfatase B |
| Description | Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Arylsulfatase B (ARSB), also known as N‐acetylgalactosamine‐4‐sulfatase, is a lysosomal enzyme that catalyzes the removal of 4‐sulfate groups from glycosaminoglycans—principally chondroitin‐4‐sulfate and dermatan sulfate—thereby facilitating their step‐wise degradation. Deficiency or mutation of ARSB disrupts this catabolic process and is the biochemical basis for mucopolysaccharidosis type VI (MPS VI; Maroteaux–Lamy syndrome), a disorder characterized by multi‐system involvement including skeletal, cardiac, and ocular abnormalities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its classical lysosomal role, ARSB activity influences diverse cellular processes. For example, environmental factors such as hypoxia or experimental silencing of ARSB result in increased chondroitin‐4‐sulfation that alters interactions with galectin‐3, leading to changes in nuclear signaling (e.g., enhanced hypoxia‐inducible factor‐1α accumulation) and modulation of inflammatory mediator binding (such as interleukin‐8)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, ARSB plays a role in extracellular matrix remodeling and cell signaling. Reduced ARSB activity has been associated with altered cell migration via modulation of RhoA activation and matrix metalloproteinase secretion, while its deficiency is linked to changes in proteoglycan expression in prostate and colonic epithelial cells that are relevant to tumor behavior and disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": " Furthermore, ARSB influences bone remodeling by contributing to the activation of other lysosomal enzymes critical for osteoclast function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Therapeutic approaches that target ARSB function are being explored. Strategies include pharmacologic read‐through of premature stop codons to restore enzyme activity in MPS VI patients"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", as well as the potential use of exogenously delivered ARSB to modify extracellular matrix composition and support tissue recovery after injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Moreover, studies in animal models and different cell types suggest that modulation of ARSB levels may have wider implications in conditions ranging from metabolic to inflammatory and neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, ARSB is central not only to the lysosomal degradation of critical glycosaminoglycans but also to the regulation of key cellular signaling pathways and extracellular matrix dynamics. Its multifaceted functions underscore its importance in normal physiology and its relevance as a therapeutic target in lysosomal storage disorders and other pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Litsa Karageorgos, Doug A Brooks, Anthony Pollard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational analysis of 105 mucopolysaccharidosis type VI patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20534"}], "href": "https://doi.org/10.1002/humu.20534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17458871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17458871"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "T Litjens, J J Hopwood "}, {"type": "b", "children": [{"type": "t", "text": "Mucopolysaccharidosis type VI: Structural and clinical implications of mutations in N-acetylgalactosamine-4-sulfatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.1190"}], "href": "https://doi.org/10.1002/humu.1190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11668612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11668612"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Francesca D'Avanzo, Alessandra Zanetti, Concetta De Filippis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mucopolysaccharidosis Type VI, an Updated Overview of the Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222413456"}], "href": "https://doi.org/10.3390/ijms222413456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34948256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34948256"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Piranit Nik Kantaputra, Hulya Kayserili, Yeliz Guven, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical manifestations of 17 patients affected with mucopolysaccharidosis type VI and eight novel ARSB mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36489"}], "href": "https://doi.org/10.1002/ajmg.a.36489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24677745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24677745"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nayerossadat Nouri, Nargesossadat Nouri, Omid Aryani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel arylsulfatase B gene mutation in three unrelated Iranian mucopolysaccharidosis type-VI patients with different phenotype severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Iran Biomed J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.6091/ibj.1049.2012"}], "href": "https://doi.org/10.6091/ibj.1049.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23023219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23023219"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sumit Bhattacharyya, Joanne K Tobacman "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0033250"}], "href": "https://doi.org/10.1371/journal.pone.0033250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22428001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22428001"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sumit Bhattacharyya, Kemal Solakyildirim, Zhenqing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2008-0482OC"}], "href": "https://doi.org/10.1165/rcmb.2008-0482OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19346317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19346317"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sumit Bhattacharyya, Joanne K Tobacman "}, {"type": "b", "children": [{"type": "t", "text": "Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-009-9253-z"}], "href": "https://doi.org/10.1007/s10585-009-9253-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19306108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19306108"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "S Bhattacharyya, L Feferman, J K Tobacman "}, {"type": "b", "children": [{"type": "t", "text": "Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.483"}], "href": "https://doi.org/10.1038/onc.2013.483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24240681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24240681"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "L Feferman, S Bhattacharyya, R Deaton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate Cancer Prostatic Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/pcan.2013.18"}], "href": "https://doi.org/10.1038/pcan.2013.18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23835622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23835622"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sanjiv V Prabhu, Sumit Bhattacharyya, Grace Guzman-Hartman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extra-lysosomal localization of arylsulfatase B in human colonic epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Histochem Cytochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1369/0022155410395511"}], "href": "https://doi.org/10.1369/0022155410395511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21378286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21378286"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Leo Feferman, Ryan Deaton, Sumit Bhattacharyya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylsulfatase B is reduced in prostate cancer recurrences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-170680"}], "href": "https://doi.org/10.3233/CBM-170680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29081414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29081414"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sandra Pohl, Alexandra Angermann, Anke Jeschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.3563"}], "href": "https://doi.org/10.1002/jbmr.3563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30075049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30075049"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rosa Bartolomeo, Elena V Polishchuk, Nicola Volpi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological read-through of nonsense ARSB mutations as a potential therapeutic approach for mucopolysaccharidosis VI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-012-9521-y"}], "href": "https://doi.org/10.1007/s10545-012-9521-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22971959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22971959"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Myungsik Yoo, Muntasir Khaled, Kurt M Gibbs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylsulfatase B improves locomotor function after mouse spinal cord injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0057415"}], "href": "https://doi.org/10.1371/journal.pone.0057415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23520469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23520469"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sumit Bhattacharyya, Leo Feferman, Joanne K Tobacman "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.561589"}], "href": "https://doi.org/10.1074/jbc.M114.561589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24778176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24778176"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "K Raj, L Berman-Booty, P Foureman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARSB gene variants causing Mucopolysaccharidosis VI in Miniature Pinscher and Miniature Schnauzer dogs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anim Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/age.13005"}], "href": "https://doi.org/10.1111/age.13005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32985704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32985704"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Erik Biros, Corey S Moran, Jane Maguire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of arylsulfatase B in carotid atherosclerosis is associated with symptoms of cerebral embolization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-04497-9"}], "href": "https://doi.org/10.1038/s41598-017-04497-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28659610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28659610"}]}]}]}
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| Synonyms | MPS6, G4S |
| Proteins | ARSB_HUMAN |
| NCBI Gene ID | 411 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ARSB has 6,467 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.
Click the + buttons to view associations for ARSB from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by ARSB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ARSB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of ARSB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ARSB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ARSB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ARSB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ARSB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with ARSB protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARSB gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ARSB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ARSB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations | phenotypes associated with ARSB gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ARSB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ARSB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with ARSB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ARSB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ARSB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with ARSB gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with ARSB gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with ARSB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of ARSB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ARSB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving ARSB gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving ARSB gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with ARSB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with ARSB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ARSB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with ARSB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with ARSB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ARSB gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARSB gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ARSB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing ARSB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with ARSB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with ARSB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with ARSB gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ARSB from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ARSB gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding ARSB protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ARSB gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ARSB gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ARSB protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing ARSB protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ARSB gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ARSB gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ARSB gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ARSB gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with ARSB gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with ARSB gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with ARSB gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for ARSB protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ARSB gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ARSB protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with ARSB gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for ARSB from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with ARSB gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| HumanCyc Pathways | pathways involving ARSB protein from the HumanCyc Pathways dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ARSB protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ARSB gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving ARSB protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ARSB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ARSB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with ARSB gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ARSB gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ARSB gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing ARSB protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ARSB protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by ARSB gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting ARSB gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ARSB gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by ARSB gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with ARSB gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ARSB from the Pathway Commons Protein-Protein Interactions dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving ARSB protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ARSB protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving ARSB protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving ARSB protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ARSB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ARSB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ARSB gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ARSB gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ARSB gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with ARSB protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ARSB gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ARSB gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ARSB gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ARSB gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ARSB protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ARSB protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with ARSB protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| WikiPathways Pathways 2024 | pathways involving ARSB protein from the WikiPathways Pathways 2024 dataset. | |
