{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ASAP1‐IT1 is a long non‐coding RNA whose expression and functional impact appear to be context dependent. In ovarian cancer, elevated ASAP1‐IT1 levels were more frequently observed in low‐grade tumors and early‐stage disease, and correlated with improved overall survival, suggesting a potential association with less aggressive tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in several other malignancies ASAP1‐IT1 is upregulated and acts as an oncogenic driver. In non‐small cell lung cancer (NSCLC), for example, increased expression of ASAP1‐IT1 not only promotes cell proliferation, invasion, and metastasis through activation of the PTEN/AKT signaling pathway, but also enhances cancer stem cell properties via a mechanism involving sequestration of miR‐509-3p and subsequent upregulation of YAP1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in cholangiocarcinoma, ASAP1‐IT1 facilitates proliferation, migration, and epithelial–mesenchymal transition by modulating components of the hedgehog signaling pathway (Smo and Gli1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in urinary bladder cancer its overexpression is associated with advanced tumor stage, poor differentiation, and enhanced stemness, contributing to an unfavorable prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, integrative bioinformatic analyses in intervertebral disc degeneration have identified ASAP1‐IT1 as a key characteristic gene, with its expression correlating with specific immune cell infiltrates, hinting at a broader role in disease pathogenesis beyond cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that while ASAP1‐IT1 may be associated with less aggressive disease in the context of ovarian cancer, its upregulation in other malignancies promotes oncogenic phenotypes by enhancing proliferation, invasion, metastasis, and cancer stem cell features—functions that are mediated through diverse signaling pathways including PTEN/AKT, hedgehog, and YAP1. This multifaceted role positions ASAP1‐IT1 as a promising candidate for further study as a diagnostic and therapeutic target across a spectrum of pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanyuan Fu, Nicoletta Biglia, Zhanwei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2016.09.021"}], "href": "https://doi.org/10.1016/j.ygyno.2016.09.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27667152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27667152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Zhang, S-B Shi, Y Zhu, et al. 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