{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent findings highlight a potential regulatory role for the non‐coding transcript ASAP1‐IT2 in cell fate conversion events relevant to skin regeneration. In one study, investigators observed that human skin fibroblasts spontaneously converted into keratinocyte‐like cells over time without the need for exogenous inducers, a phenomenon that may involve modulation by intrinsic regulators such as ASAP1‐IT2 (1,2). This transcript, derived from an intronic region of the ASAP1 gene, is proposed to participate in the reprogramming process by influencing signaling pathways that govern both proliferation and epithelial differentiation. Such a mechanism could help overcome the challenge of low expansion rates associated with keratinocytes, thereby enhancing their utility as seed cells for wound healing and skin reconstruction. Overall, the activity of ASAP1‐IT2 represents a promising molecular target for future studies aimed at optimizing cell reprogramming strategies in regenerative medicine (1,2).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "<br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br>\n (2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fang Zhang, Dandan Zhang, Kai Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spontaneous evolution of human skin fibroblasts into wound-healing keratinocyte-like cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.31526"}], "href": "https://doi.org/10.7150/thno.31526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31410210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31410210"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yaxuan Sun, Jing Wang, Bin Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elucidating the Molecular Mechanism of Ischemic Stroke Using Integrated Analysis of miRNA, mRNA, and lncRNA Expression Profiles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Integr Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnint.2021.638114"}], "href": "https://doi.org/10.3389/fnint.2021.638114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34483854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34483854"}]}]}]}