ASIC1 Gene

HGNC Family	Ion channels
Name	acid sensing (proton gated) ion channel 1
Description	This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Acid‐sensing ion channel 1 (ASIC1) is a proton‐gated cation channel widely expressed in neurons that translates extracellular acidosis into diverse cellular responses. In the central nervous system, activation of ASIC1 contributes to neurodegenerative processes—for example, in inflammatory demyelinating disorders where ASIC1 promotes axonal degeneration and its inhibition lessens clinical deficits in experimental models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although broadly distributed throughout the adult brain, ASIC1 does not appear to be concentrated in synaptic microdomains, suggesting a role in non‐synaptic pH sensing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Under pathologic conditions such as ischemia, ASIC1 activation not only mediates Na⁺ and Ca²⁺ influx but can also initiate a non‐conducting, pro‐necroptotic cascade by recruiting receptor‐interacting protein 1 (RIP1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " ASIC1 function is further modulated by interacting proteins: for instance, p11 selectively enhances the surface expression and activity of ASIC1a"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", whereas SGK1.1 downregulates ASIC1 levels, potentially providing neuroprotection during ischemic insult."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Detailed structure–function analyses have revealed that ASIC1 contains distinct extracellular proton coordination sites that are essential for channel gating."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in glioblastoma cells ASIC1 forms hybrid complexes with epithelial sodium channel subunits and associates with regulatory kinases such as CaMKII, thereby influencing tumor cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of ASIC1 in mediating acid‐induced neuronal injury and tumor biology, and they position ASIC1 as a promising therapeutic target in conditions ranging from neuroinflammation and ischemia to cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Manuel A Friese, Matthew J Craner, Ruth Etzensperger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1668"}], "href": "https://doi.org/10.1038/nm1668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17994101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17994101"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Diego Alvarez de la Rosa, Stefan R Krueger, Annette Kolar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2002.030692"}], "href": "https://doi.org/10.1113/jphysiol.2002.030692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509480"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi-Zhi Wang, Jing-Jing Wang, Yu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.05682"}], "href": "https://doi.org/10.7554/eLife.05682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26523449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26523449"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "A Soren Leonard, Olena Yermolaieva, Alesia Hruska-Hageman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.252782799"}], "href": "https://doi.org/10.1073/pnas.252782799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12578970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12578970"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria F Arteaga, Tatjana Coric, Christoph Straub, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0800958105"}], "href": "https://doi.org/10.1073/pnas.0800958105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18334630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18334630"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aram J Krauson, Anna C Rued, Marcelo D Carattino "}, {"type": "b", "children": [{"type": "t", "text": "Independent contribution of extracellular proton binding sites to ASIC1a activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.504324"}], "href": "https://doi.org/10.1074/jbc.M113.504324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24142696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24142696"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Niren Kapoor, Rafal Bartoszewski, Yawar J Qadri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.037390"}], "href": "https://doi.org/10.1074/jbc.M109.037390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19561078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19561078"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xu Sun, Dan Zhao, Yong-Li Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2777"}], "href": "https://doi.org/10.3892/or.2013.2777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24100685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24100685"}]}]}]}
Synonyms	ASIC, BNAC2, ACCN2
Proteins	ASIC1_HUMAN
NCBI Gene ID	41
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ASIC1 has 6,513 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for ASIC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ASIC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ASIC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ASIC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ASIC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ASIC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ASIC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ASIC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ASIC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ASIC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ASIC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ASIC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ASIC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ASIC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ASIC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ASIC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ASIC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ASIC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ASIC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ASIC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ASIC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ASIC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ASIC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ASIC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ASIC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ASIC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ASIC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ASIC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ASIC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ASIC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ASIC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ASIC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ASIC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ASIC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ASIC1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ASIC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ASIC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ASIC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ASIC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ASIC1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ASIC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ASIC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.