{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ASMTL‐AS1 is a long non‐coding RNA that plays context‐dependent roles in cancer by modulating key signaling pathways through interactions with microRNAs and mRNA stabilizing proteins. In lung adenocarcinoma, ASMTL‐AS1 is downregulated, and its overexpression suppresses tumor growth and promotes ferroptosis by recruiting U2AF2 to stabilize SAT1 mRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric cancer, reduced ASMTL‐AS1 expression is associated with advanced disease stage and poor overall survival, where it acts as a tumor suppressor by inhibiting proliferation, migration, and invasion via regulation of miR‐1270."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, in osteosarcoma ASMTL‐AS1 is elevated and functions as an oncogene by serving as a competing endogenous RNA for miR‐342‑3p, resulting in upregulation of ADAM9 and enhanced malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma (HCC), data indicate divergent roles for ASMTL‐AS1: one study (with partially reported results) suggests its involvement in HCC malignancy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", whereas another study shows that in residual HCC after insufficient radiofrequency ablation, ASMTL‐AS1 is upregulated and promotes tumor aggressiveness through the miR‐342‑3p/NLK/YAP axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In triple‐negative breast cancer, ASMTL‐AS1 is markedly downregulated; its restoration suppresses tumor cell colony formation, activity, and invasion by sponging miR‐1228‑3p to upregulate SOX17, thereby inactivating the oncogenic Wnt/β‑catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in papillary thyroid carcinoma, decreased ASMTL‐AS1 is associated with larger tumor size and advanced stage, while its overexpression inhibits proliferation and glycolysis via sequestering miR‐93‑3p and miR‐660 to elevate FOXO1 levels, which in turn reinforces ASMTL‐AS1 expression through a positive feedback loop."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that ASMTL‐AS1 functions as a context‐specific regulator—acting as a tumor suppressor in lung adenocarcinoma, gastric cancer, triple‐negative breast cancer, and papillary thyroid carcinoma, while promoting tumor progression in osteosarcoma and certain HCC settings. Its ability to modulate microRNA activity and stabilize specific mRNAs positions ASMTL‐AS1 as a potential prognostic biomarker and therapeutic target across a spectrum of human cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiujie Sui, Na Hu, Ze Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/pin.13158"}], "href": "https://doi.org/10.1111/pin.13158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34658100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34658100"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenhe Song, Jian Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ASMTL-AS1/microRNA-1270 differentiate prognostic groups in gastric cancer and influence cell proliferation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2021063"}], "href": "https://doi.org/10.1080/21655979.2021.2021063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34986743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34986743"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chengcai Hou, Fei Sun, Mingyue Sun "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ASMTL-AS1 deteriorates the oncogenicity of osteosarcoma by decoying microRNA-342-3p and consequently raising ADAM9 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.09.049"}], "href": "https://doi.org/10.1016/j.bbrc.2021.09.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34597997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34597997"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanjie Mou, Qinguo Sun "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2012628"}], "href": "https://doi.org/10.1080/21655979.2021.2012628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34859735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34859735"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dening Ma, Xinyi Gao, Zhuo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-transferred long non-coding RNA ASMTL-AS1 contributes to malignant phenotypes in residual hepatocellular carcinoma after insufficient radiofrequency ablation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12795"}], "href": "https://doi.org/10.1111/cpr.12795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32722884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32722884"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jie Sun, Xiaohua Li, Enqiao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel tumor suppressor ASMTL-AS1 regulates the miR-1228-3p/SOX17/β-catenin axis in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13000-021-01105-3"}], "href": "https://doi.org/10.1186/s13000-021-01105-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34006305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34006305"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhiyi Feng, Rong Chen, Nanqi Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ASMTL-AS1 inhibits tumor growth and glycolysis by regulating the miR-93-3p/miR-660/FOXO1 axis in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.117298"}], "href": "https://doi.org/10.1016/j.lfs.2020.117298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31953163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31953163"}]}]}]}