{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ATP1A1‐AS1 is an antisense long noncoding RNA that has emerged as a potential biomarker in several pathological conditions. In thyroid cancer, ATP1A1‐AS1 was identified among a panel of downregulated lncRNAs whose reduced expression correlated with longer disease‐free survival, suggesting that its loss may be linked to a less aggressive tumor phenotype. Bioinformatics analyses in this context indicated that ATP1A1‐AS1 might regulate key biological processes such as RNA metabolism, cell migration, organelle assembly, tRNA modification, and hormone levels (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In clear cell renal cell carcinoma, ATP1A1‐AS1 is part of an immune‐related lncRNA signature. Notably, its expression shows an inverse trend with tumor T‐stage, with lower levels observed in more advanced stages. This suggests a potential protective role, as diminished ATP1A1‐AS1 levels may contribute to tumor progression via altered immune microenvironment regulation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the setting of acute renal allograft rejection, ATP1A1‐AS1 was among four lncRNAs selected to construct a prognostic risk model predicting graft loss. Its expression was found to correlate with specific immune cell infiltrates and inflammatory signaling pathways (including those mediated by Toll‐like and NOD‐like receptors), highlighting a potential functional role in modulating the immune response during allograft injury (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies suggest that ATP1A1‐AS1 may serve as a valuable prognostic biomarker and may be involved in the regulation of cellular metabolism, migration, and immune responses in both tumorigenesis and transplant rejection.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuansheng Rao, Haiying Liu, Xiaojuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Analysis Identifies Differently Expressed lncRNAs as Novel Biomarkers for the Prognosis of Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3651051"}], "href": "https://doi.org/10.1155/2020/3651051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32377223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32377223"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuanbin Jiang, Xin Gou, Zongjie Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics profiling integrating a three immune-related long non-coding RNA signature as a prognostic model for clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01242-7"}], "href": "https://doi.org/10.1186/s12935-020-01242-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32435157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32435157"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zedan Zhang, Yanlin Tang, Hongkai Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying 4 Novel lncRNAs as Potential Biomarkers for Acute Rejection and Graft Loss of Renal Allograft."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/2415374"}], "href": "https://doi.org/10.1155/2020/2415374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33376751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33376751"}]}]}]}