{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Abstract: ATP1B3‑AS1 is an emerging long non‑coding RNA (lncRNA) implicated in breast cancer by contributing to the regulation of diverse intracellular and intercellular signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the breast cancer context described in this abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", lncRNAs such as ATP1B3‑AS1 are understood to modulate key cellular processes—including estrogen receptor α (ERα) levels and activity, cell proliferation, invasion, migration, apoptosis, and stemness. The dysregulation of these lncRNAs in tumor tissues indicates a role either as oncogenic drivers or tumor suppressors. Furthermore, as part of the repertoire of non‑coding RNAs that can be packaged into exosomes, ATP1B3‑AS1 may also participate in intercellular communication, influencing both local and systemic tumor behavior. Collectively, these functions highlight the potential of ATP1B3‑AS1 to serve as both a biomarker and a therapeutic target in breast cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carolyn M Klinge "}, {"type": "b", "children": [{"type": "t", "text": "Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4040040"}], "href": "https://doi.org/10.3390/ncrna4040040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545127"}]}]}]}