{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nATP5F1C encodes the gamma subunit of the mitochondrial ATP synthase F₁ complex, a key component of the oxidative phosphorylation machinery that produces ATP – the cellular energy currency required for nearly every biological process. Although fundamental to energy metabolism in all cells, ATP5F1C is not directly discussed in the provided abstracts. In the broader context of cell function, its energy‐generating activity underpins many energy‐intensive processes—including some aspects of immune cell activation and signaling—even though these studies focused primarily on signal transduction pathways mediated by kinases such as Syk and adaptor molecules like CARD9."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, the collection of abstracts provided centers on diverse aspects of immune receptor signaling—including studies of dectin‐1–Syk–CARD9 pathways, integrin‐ and Fc receptor–mediated responses, and inflammasome activation in contexts ranging from antifungal immunity to platelet function and lymphatic development. These studies highlight the roles of kinases (especially Syk), adaptor proteins, and downstream effectors in mediating proinflammatory and regulatory responses. While these signaling cascades are energy‐dependent processes that rely on robust mitochondrial function to support cell activation and survival, none of the abstracts directly address ATP5F1C or its mitochondrial bioenergetic role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Achim Obergfell, Koji Eto, Attila Mocsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200112113"}], "href": "https://doi.org/10.1083/jcb.200112113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11940607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11940607"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Attila Mócsai, Meijuan Zhou, Fanying Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syk is required for integrin signaling in neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1074-7613(02)00303-5"}], "href": "https://doi.org/10.1016/s1074-7613(02"}, {"type": "t", "text": "00303-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11970878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11970878"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Farhad Abtahian, Anastasia Guerriero, Eric Sebzda, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A Ras activation pathway dependent on Syk phosphorylation of protein kinase C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1633695100"}], "href": "https://doi.org/10.1073/pnas.1633695100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12881490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12881490"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marina Ulanova, Lakshmi Puttagunta, Marcelo Marcet-Palacios, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-05-158469"}], "href": "https://doi.org/10.1182/blood-2008-05-158469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818389"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Laura Helming, Elena Tomasello, Themis R Kyriakides, et al. 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