{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ATP5MGL is a protein implicated in mitochondrial energy metabolism, and its detection and characterization have now been supported by multiple studies. In one study under the chromosome‐centric human proteome project, ATP5MGL was identified among the “missing” proteins on chromosome 22, where advanced proteogenomics approaches helped refine its gene structure and confirm its translation start site, thereby underscoring its potential role as part of the ATP synthase complex involved in cellular energy production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary work using the human neuroblastoma cell line SH-SY5Y—widely utilized as a model for neurodegenerative diseases—has further emphasized the importance of intact mitochondrial pathways. In this context, ensuring the integrity of ATP synthase components such as ATP5MGL is critical for maintaining proper energy metabolism, which is particularly relevant in studies of Parkinson’s disease and related disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, investigations into seasonal influences on muscle transcriptomes in rainbow trout have revealed that gene expression differences, including those of mitochondrial components, likely contribute to altered energy demands during growth and metabolic cycling. Such findings hint at a broader impact for proteins like ATP5MGL in adjusting mitochondrial function in response to environmental cues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies support a role for ATP5MGL in the regulation of mitochondrial ATP synthesis and energy homeostasis across diverse biological contexts and conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qing Wang, Mengge Li, Yu Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.38704"}], "href": "https://doi.org/10.7150/thno.38704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32089737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32089737"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sneha M Pinto, Srikanth S Manda, Min-Sik Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional annotation of proteome encoded by human chromosome 22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr401169d"}], "href": "https://doi.org/10.1021/pr401169d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24669763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24669763"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Abhimanyu Krishna, Maria Biryukov, Christophe Trefois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-15-1154"}], "href": "https://doi.org/10.1186/1471-2164-15-1154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25528190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25528190"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Roy G Danzmann, Andrea L Kocmarek, Joseph D Norman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome profiling in fast versus slow-growing rainbow trout across seasonal gradients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2363-5"}], "href": "https://doi.org/10.1186/s12864-016-2363-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26768650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26768650"}]}]}]}