AUTS2 Gene

Name	autism susceptibility candidate 2
Description	This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2014]
Summary	{"type": "root", "children": [{"type": "t", "text": "<div>\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The AUTS2 (autism susceptibility candidate 2) gene plays a multifaceted role in neurodevelopment by modulating gene expression programs that are essential for proper neuronal differentiation, migration, and regional specification. In several neuropsychiatric and neurodevelopmental studies, rare copy number variations and point mutations in AUTS2 have been associated with disorders including autism spectrum disorders, intellectual disability, epilepsy, and behavioral abnormalities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Expression analyses in the developing mouse brain reveal that AUTS2 is prominently expressed in the cerebral cortex and cerebellum, consistent with its involvement in establishing higher cognitive functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the molecular level, AUTS2 functions as a context‐dependent regulator of transcription. It is directly activated by upstream factors such as TBR1—which binds the promoter of AUTS2 to guide frontal cortical identity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "—and operates as a critical component of a non‐canonical Polycomb repressive complex 1 (PRC1–AUTS2). In this complex, AUTS2 redirects the traditional repressive function of PRC1 toward transcriptional activation by recruiting the histone acetyltransferase p300, an activity modulated by associated kinases such as CK2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, functional genomic analyses have demonstrated that AUTS2 binds to promoters and enhancers in the developing forebrain, thereby orchestrating neuronal gene networks essential for neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its developmental roles, genetic association studies have linked AUTS2 variants with various neurobehavioral traits. For instance, polymorphisms in AUTS2 have been correlated with differences in alcohol consumption"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and heroin dependence, where reduced AUTS2 expression appears to confer increased susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Experimental models further support the gene’s functional relevance; knockdown studies in zebrafish result in microcephaly, neuronal loss, and impaired motility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and heterozygous deletion of Auts2 in mice leads to deficits in exploratory behavior, cognitive function, and associative memory."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Interestingly, aberrant AUTS2 function is not confined to neurodevelopment. In hematologic malignancies, for example, a recurrent PAX5–AUTS2 fusion has been identified in children with B‐cell precursor acute lymphoblastic leukemia, implicating the gene in transcriptional deregulation beyond the nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Furthermore, genetic variants in AUTS2 have also been implicated in schizophrenia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", underscoring its broad impact on brain function and behavior."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, AUTS2 is a key regulator of neuronal gene expression networks that influences brain development and function by integrating upstream signaling, epigenetic modulation, and transcriptional control. Its disruption through genetic variation or structural rearrangement contributes to a spectrum of neurodevelopmental and neuropsychiatric disorders, highlighting its central role in both normal brain function and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "15"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n</div>"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Elia, X Gai, H M Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2009.57"}], "href": "https://doi.org/10.1038/mp.2009.57"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546859"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Heather C Mefford, Hiltrud Muhle, Philipp Ostertag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000962"}], "href": "https://doi.org/10.1371/journal.pgen.1000962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20502679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20502679"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gea Beunders, Els Voorhoeve, Christelle Golzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.12.011"}], "href": "https://doi.org/10.1016/j.ajhg.2012.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23332918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23332918"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gea Beunders, Sonja A de Munnik, Nathalie Van der Aa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two male adults with pathogenic AUTS2 variants, including a two-base pair deletion, further delineate the AUTS2 syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2014.173"}], "href": "https://doi.org/10.1038/ejhg.2014.173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25205402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25205402"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Francesco Bedogni, Rebecca D Hodge, Branden R Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2009.11.005"}], "href": "https://doi.org/10.1016/j.gep.2009.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19948250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19948250"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Francesco Bedogni, Rebecca D Hodge, Gina E Elsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1002285107"}], "href": "https://doi.org/10.1073/pnas.1002285107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20615956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20615956"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhonghua Gao, Pedro Lee, James M Stafford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An AUTS2-Polycomb complex activates gene expression in the CNS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13921"}], "href": "https://doi.org/10.1038/nature13921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25519132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25519132"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sanxiong Liu, Kimberly A Aldinger, Chi Vicky Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.09.020"}], "href": "https://doi.org/10.1016/j.molcel.2021.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34637754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34637754"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "N Oksenberg, G D E Haliburton, W L Eckalbar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2014.78"}], "href": "https://doi.org/10.1038/tp.2014.78"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25180570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25180570"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gunter Schumann, Lachlan J Coin, Anbarasu Lourdusamy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1017288108"}], "href": "https://doi.org/10.1073/pnas.1017288108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21471458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21471458"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yun-Hsiang Chen, Ding-Lieh Liao, Chih-Hao Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of AUTS2 as a susceptibility gene of heroin dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Alcohol Depend (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.drugalcdep.2012.08.029"}], "href": "https://doi.org/10.1016/j.drugalcdep.2012.08.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22995765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22995765"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nir Oksenberg, Laurie Stevison, Jeffrey D Wall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function and regulation of AUTS2, a gene implicated in autism and human evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1003221"}], "href": "https://doi.org/10.1371/journal.pgen.1003221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23349641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23349641"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kei Hori, Taku Nagai, Wei Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0145979"}], "href": "https://doi.org/10.1371/journal.pone.0145979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26717414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26717414"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dagmar Denk, Karin Nebral, Jutta Bradtke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2012.04.015"}], "href": "https://doi.org/10.1016/j.leukres.2012.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22578776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22578776"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bao Zhang, Yue-Hong Xu, Shu-Guang Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study identifying a new susceptibility gene (AUTS2) for schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms151119406"}], "href": "https://doi.org/10.3390/ijms151119406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25347278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25347278"}]}]}]}
Synonyms	MRD26, FBRSL2
Proteins	AUTS2_HUMAN
NCBI Gene ID	26053
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AUTS2 has 11,967 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for AUTS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AUTS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AUTS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AUTS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AUTS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AUTS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AUTS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AUTS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AUTS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AUTS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AUTS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AUTS2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AUTS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AUTS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AUTS2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AUTS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AUTS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AUTS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AUTS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with AUTS2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AUTS2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AUTS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AUTS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AUTS2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AUTS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AUTS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AUTS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AUTS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AUTS2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AUTS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with AUTS2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AUTS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with AUTS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with AUTS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AUTS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AUTS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AUTS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AUTS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AUTS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AUTS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AUTS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AUTS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.