{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n B4GALT1‐AS1 is an oncogenic long non‐coding RNA that has been implicated in multiple aspects of tumor progression and metabolism. In osteosarcoma and colon cancer models, increased expression of B4GALT1‐AS1 enhances cancer cell stemness, migration, and chemoresistance. Mechanistic studies in these models have revealed that B4GALT1‐AS1 binds to RNA‐binding proteins—such as HuR—to stabilize YAP mRNA and modulate YAP’s subcellular localization and transcriptional activity, thereby promoting oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, B4GALT1‐AS1 originates from a bidirectional promoter region adjacent to the B4GALT1 gene, and its transcripts exhibit significant complementarity with B4GALT1 mRNA. This suggests a role in the post‐transcriptional regulation of gene expression which may influence cell–matrix interactions, metastatic progression, and drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Evidence from non‐small cell lung cancer indicates that B4GALT1‐AS1 can act as a molecular sponge for miR‐144-3p, resulting in the upregulation of ZEB1 and further facilitating tumor proliferation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in cancer, the human homolog of B4GALT1‐AS1—identified in the context of nonalcoholic fatty liver disease—functions in metabolic regulation. Reduced levels of this lncRNA in hepatocytes are associated with dysregulated glucose and lipid metabolism. Mechanistically, it recruits hnRNPA1 to enhance the translation of calmodulin, thereby activating the PI3K/Akt pathway and repressing mTOR/SREBP-1C signaling, which ameliorates hyperglycemia and steatosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight B4GALT1‐AS1 as a multifunctional regulator that contributes to tumor aggressiveness through modulation of key oncogenic pathways and also plays a part in metabolic homeostasis. Its varied roles across different tissues and disease contexts underscore its potential as both a biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhikun Li, Yi Wang, Ruixi Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12504"}], "href": "https://doi.org/10.1111/cpr.12504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30182452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30182452"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Zhang, Zhixue Fang, Xiong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA B4GALT1-AS1 promotes colon cancer cell stemness and migration by recruiting YAP to the nucleus and enhancing YAP transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28489"}], "href": "https://doi.org/10.1002/jcp.28489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30912138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30912138"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mohammed A Ibrahim Al-Obaide, Hytham Alobydi, Abdelsalam G Abdelsalam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3136"}], "href": "https://doi.org/10.3892/ijo.2015.3136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26315939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26315939"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shi-Wei Liu, Pu Yang, Fan-Nian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA B4GALT1-AS1 promotes non-small cell lung cancer cell growth via increasing ZEB1 level by sponging miR-144-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-22-296"}], "href": "https://doi.org/10.21037/tcr-22-296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35402178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35402178"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Junpei Wang, Weili Yang, Zhenzhen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db17-0799"}], "href": "https://doi.org/10.2337/db17-0799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29382663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29382663"}]}]}]}