{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BAALC‐AS1 is a long non‐coding RNA (lncRNA) with context‐dependent roles in human disease. In esophageal squamous cell carcinoma, BAALC‐AS1 is highly up‐regulated and functions as an oncogenic driver that promotes cancer cell proliferation, migration, and invasion. Mechanistically, BAALC‐AS1 binds directly to the RNA‐binding protein G3BP2, thereby blocking G3BP2‐mediated degradation of the c‐Myc mRNA 3′‐UTR. This interaction results in the accumulation of c‐Myc, which subsequently acts as a transcription factor to further enhance BAALC‐AS1 expression, establishing a positive feedback loop that supports tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, BAALC‐AS1 has been identified as a key component of a circulating non‐coding RNA signature associated with early renal damage in hypertensive patients. Here, it participates in a broader transcriptional regulatory network that influences critical pathways regulating the integrity of the glomerular filtration barrier and tubular reabsorption."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongyue Zhang, Yan Wang, Weimin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Commun (Lond) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cac2.12127"}], "href": "https://doi.org/10.1002/cac2.12127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33476486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33476486"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angela L Riffo-Campos, Javier Perez-Hernandez, Ana Ortega, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23020823"}], "href": "https://doi.org/10.3390/ijms23020823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35055008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35055008"}]}]}]}