BAG5 Gene

Name	BCL2-associated athanogene 5
Description	The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>BAG5 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n BAG5, a unique member of the BAG protein family with multiple BAG domains, functions as a critical co‐chaperone that modulates protein quality control through its interactions with various chaperones and E3 ubiquitin ligases. In neurodegenerative diseases, BAG5 directly binds to parkin and Hsp70, thereby inhibiting parkin’s E3 ubiquitin ligase activity, promoting its sequestration within protein aggregates, and ultimately enhancing dopaminergic neuronal death and pathogenic protein accumulation ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "]. Moreover, BAG5 stabilizes PINK1 by reducing its ubiquitination, thereby protecting mitochondrial function under oxidative stress ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]. In contrast, under conditions of severe mitochondrial damage, BAG5 impairs mitophagy by suppressing Parkin recruitment and enhances Parkin-mediated degradation of Mcl-1, acting as a molecular switch to promote cell death; it also directly stabilizes Parkin by interfering with its proteasomal degradation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. Additionally, elevated BAG5 expression observed in Alzheimer’s disease models may confer neuroprotective effects against amyloid-β toxicity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in neurodegeneration, BAG5 is emerging as an important regulator in cancer. It is overexpressed in malignant tissues such as prostate, ovarian, and pancreatic cancers, where it supports cell survival under endoplasmic reticulum stress by interacting with the ER chaperone GRP78/BiP and modulating the unfolded protein response ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "]. In epithelial ovarian and pancreatic carcinomas, tumor suppressor microRNAs (e.g. miR-127-3p) target BAG5; conversely, upregulation of BAG5 reverses these suppressive effects, thereby promoting cell proliferation, invasion, and chemoresistance ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "]. Furthermore, in hepatocellular carcinoma, post-translational methylation of BAG5 regulates HSC70 stability, affecting autophagic flux and drug resistance ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "]. In endothelial cells, BAG5 overexpression affords protection against catecholamine-induced stress by attenuating ER stress, oxidative stress, and inflammation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that BAG5 plays multifaceted roles in diverse biological contexts. By modulating protein ubiquitination, mitochondrial integrity, autophagy, and apoptosis, BAG5 can either promote neurodegeneration—via impairment of mitophagy and enhancement of toxic protein aggregation—or support cancer cell survival by regulating stress response pathways. This duality positions BAG5 as a promising therapeutic target in both neurodegenerative disorders and oncologic settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Suneil K Kalia, Sang Lee, Patrice D Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2004.11.026"}], "href": "https://doi.org/10.1016/j.neuron.2004.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15603737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15603737"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lorraine V Kalia, Suneil K Kalia, Hien Chau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0014695"}], "href": "https://doi.org/10.1371/journal.pone.0014695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21358815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21358815"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiang-Qian Che, Bei-Sha Tang, Hong-Feng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00207454.2014.940585"}], "href": "https://doi.org/10.3109/00207454.2014.940585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25006867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25006867"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mitchell L De Snoo, Erik L Friesen, Yu Tong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2132-x"}], "href": "https://doi.org/10.1038/s41419-019-2132-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31787745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31787745"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuejing Wang, Jifeng Guo, Erkang Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0086276"}], "href": "https://doi.org/10.1371/journal.pone.0086276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24475098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24475098"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xuejing Wang, Jifeng Guo, Hong Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Direct interaction between BAG5 protein and Parkin protein]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Nan Da Xue Xue Bao Yi Xue Ban (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3969/j.issn.1672-7347.2010.11.007"}], "href": "https://doi.org/10.3969/j.issn.1672-7347.2010.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21131737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21131737"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Valerie P Tan, Jeffrey M Smith, Michelle Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1965-7"}], "href": "https://doi.org/10.1038/s41419-019-1965-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31570704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31570704"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ke Guo, Liuhong Li, Gang Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bag5 protects neuronal cells from amyloid β-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-014-0433-1"}], "href": "https://doi.org/10.1007/s12031-014-0433-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25367796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25367796"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-96"}], "href": "https://doi.org/10.1186/1471-2407-13-96"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23448667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23448667"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Linlin Bi, Qian Yang, Jiani Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5055"}], "href": "https://doi.org/10.3892/or.2016.5055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27571744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27571744"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuan Yu, Lei Liu, Ruirui Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-127 is aberrantly downregulated and acted as a functional tumor suppressor in human pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5270-0"}], "href": "https://doi.org/10.1007/s13277-016-5270-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27571739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27571739"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Noélia Che, Kai-Yu Ng, Tin-Lok Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.11.002"}], "href": "https://doi.org/10.1016/j.canlet.2020.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33186656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33186656"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hang Zhu, Maoxiang Zhao, Yundai Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29904"}], "href": "https://doi.org/10.1002/jcp.29904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32583430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32583430"}]}]}]}
Synonyms	BAG-5
Proteins	BAG5_HUMAN
NCBI Gene ID	9529
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BAG5 has 5,695 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for BAG5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BAG5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BAG5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BAG5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BAG5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BAG5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BAG5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BAG5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BAG5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BAG5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BAG5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BAG5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BAG5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BAG5 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BAG5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BAG5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BAG5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BAG5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BAG5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BAG5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing BAG5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing BAG5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BAG5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BAG5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing BAG5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BAG5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BAG5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BAG5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BAG5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BAG5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving BAG5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BAG5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BAG5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BAG5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BAG5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BAG5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BAG5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BAG5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BAG5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with BAG5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with BAG5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of BAG5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.