BAG6 Gene

Name	BCL2-associated athanogene 6
Description	This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BAG6, also known as BAT3 or Scythe, is a multifunctional molecular scaffold that integrates diverse cellular functions, including modulation of immune responses, regulation of the DNA damage response, apoptosis, and autophagy. In the immune system, intracellular BAG6 binds to the inhibitory receptor Tim‑3, thereby repressing its function and protecting T cells from exhaustion and galectin‑9–mediated cell death; this activity promotes T helper cell proliferation and pro‑inflammatory cytokine production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, BAG6 can be released extracellularly—often packaged within exosomes—where it serves as a ligand for the natural cytotoxicity receptor NKp30, triggering NK cell–mediated cytotoxicity, enhancing cross‐talk with dendritic cells, and aiding tumor rejection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of genomic integrity, BAG6 interacts with the histone methyltransferase DOT1L to promote H3K79 dimethylation, which is critical for the formation of 53BP1 foci following DNA damage and thus for proper repair processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " BAG6 also functions in apoptosis: caspase‑3 cleaves BAG6, an event that is essential for apoptotic signaling induced by agents such as ricin, with the resulting fragments mediating characteristic morphological changes of apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, BAG6 is indispensable for autophagy where it modulates the intracellular localization of the acetyltransferase p300, thereby fine‑tuning the acetylation of key substrates such as p53 and ATG7 to regulate autophagic flux."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, BAG6 contributes to the regulation of macrophage activation by being released from these cells and down‑regulating both nitric oxide and pro‑inflammatory cytokine production upon stimulation, underscoring its broader role in controlling immune effector functions in response to pathogens."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these studies establish BAG6 as a central mediator at the crossroads of immune regulation, genomic maintenance, apoptosis, and autophagy, and underscore its potential as a therapeutic target in diseases marked by immune dysregulation, genomic instability, and defective cell death pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Manu Rangachari, Chen Zhu, Kaori Sakuishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2871"}], "href": "https://doi.org/10.1038/nm.2871"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22863785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22863785"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elke Pogge von Strandmann, Venkateswara Rao Simhadri, Bastian von Tresckow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.10.010"}], "href": "https://doi.org/10.1016/j.immuni.2007.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18055229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18055229"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Venkateswara Rao Simhadri, Katrin S Reiners, Hinrich P Hansen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0003377"}], "href": "https://doi.org/10.1371/journal.pone.0003377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18852879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18852879"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Timothy P Wakeman, Qinhong Wang, Junjie Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2012.50"}], "href": "https://doi.org/10.1038/emboj.2012.50"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22373577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22373577"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fabienne Desmots, Helen R Russell, Youngsoo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.23.10329-10337.2005"}], "href": "https://doi.org/10.1128/MCB.25.23.10329-10337.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16287848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16287848"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu-Hauh Wu, Sheue-Fang Shih, Jung-Yaw Lin "}, {"type": "b", "children": [{"type": "t", "text": "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307049200"}], "href": "https://doi.org/10.1074/jbc.M307049200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14960581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14960581"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Salwa Sebti, Christine Prébois, Esther Pérez-Gracia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1313618111"}], "href": "https://doi.org/10.1073/pnas.1313618111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24591579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24591579"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ajay Grover, Angelo A Izzo "}, {"type": "b", "children": [{"type": "t", "text": "BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040836"}], "href": "https://doi.org/10.1371/journal.pone.0040836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22808273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22808273"}]}]}]}
Synonyms	BAG-6, D6S52E, BAT3, G3
Proteins	BAG6_HUMAN
NCBI Gene ID	7917
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BAG6 has 7,613 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.

Click the + buttons to view associations for BAG6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BAG6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by BAG6 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BAG6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BAG6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BAG6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BAG6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BAG6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BAG6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BAG6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BAG6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of BAG6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BAG6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BAG6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with BAG6 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BAG6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with BAG6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BAG6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BAG6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BAG6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of BAG6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BAG6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BAG6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing BAG6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BAG6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BAG6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BAG6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BAG6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BAG6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BAG6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with BAG6 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BAG6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for BAG6 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with BAG6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BAG6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BAG6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BAG6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BAG6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BAG6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BAG6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BAG6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BAG6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.