{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BAIAP2‐AS1 is a long noncoding RNA that has emerged as an important regulator in cancer. Recent transcriptome analyses in HBV‐related hepatocellular carcinoma predicted a functional role for BAIAP2‐AS1 through co‐expression network and gene set enrichment analyses, suggesting its involvement in oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In line with these findings, experimental studies in hepatocellular carcinoma have shown that BAIAP2‐AS1 expression is markedly upregulated by the transcription factor E2F1. Elevated BAIAP2‐AS1 then promotes tumor cell proliferation and metastasis by modulating a microRNA–mediated pathway—in particular, by acting on the miR‑361‑3p/SOX4 axis—to enhance SOX4 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, BAIAP2‐AS1 is part of a robust 15‐lncRNA signature that has prognostic relevance in cervical squamous cell carcinoma, underscoring its potential utility as a biomarker for patient survival and as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies indicate that aberrant expression of BAIAP2‐AS1 supports tumor progression through the regulation of key oncogenic pathways, and that it may serve both as a prognostic marker and as a promising target for future anticancer therapies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xianli Gong, Wei Wei, Lan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of long non-coding RNA expression profiles in hepatitis B virus-related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9880"}], "href": "https://doi.org/10.18632/oncotarget.9880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27285756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27285756"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Yang, Hong Ge, De-Qing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6256369"}], "href": "https://doi.org/10.1155/2021/6256369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34616498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34616498"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaogang Mao, Xiaomin Qin, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2017.12.011"}], "href": "https://doi.org/10.1016/j.ygyno.2017.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29525275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29525275"}]}]}]}