{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA BBOX1‐AS1 is emerging as a critical regulator in the development and progression of a diverse range of human malignancies as well as in other disorders. It is frequently upregulated in tumors such as cervical cancer, non‐small cell lung cancer, colorectal cancer, ovarian cancer, pituitary adenoma, esophageal squamous cell carcinoma, nasopharyngeal carcinoma, oral squamous cell carcinoma, gastric cancer, and lung squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, BBOX1‐AS1 predominantly acts as a competitive endogenous RNA that “sponges” various tumor‐suppressive microRNAs – including miR‑361‑3p, miR‑27a‑5p, miR‑125b‑5p/miR‑125a‑5p, miR‑3940‑3p, and miR‑146b – thereby relieving the inhibition on their downstream oncogenic targets. In cervical, colorectal, and ovarian cancers, BBOX1‐AS1 binds to miR‑361‑3p leading to upregulation of targets such as HOXC6, SH2B1, and PODXL that in turn promote cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In non‐small cell lung cancer, BBOX1‐AS1 sponges miR‑27a‑5p to enhance the activity of MELK/FAK signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and in pituitary adenoma, it modulates the miR‑361‑3p/E2F1 axis to stimulate malignant features."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in esophageal squamous cell carcinoma its upregulation promotes HOXB7 expression and the subsequent activation of the Wnt/β‐catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In nasopharyngeal and oral squamous cell carcinomas as well as gastric cancer, BBOX1‐AS1 acts through association with miR‑3940‑3p to relieve suppression on KPNA2, LAMC2, or BIRC5, thereby facilitating tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, a competing endogenous RNA network analysis in cervical cancer implicated BBOX1‐AS1 in the regulation of CDKN2A via miR‑125b‑5p/miR‑125a‑5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Beyond its roles in tumorigenesis, BBOX1‐AS1 has also been linked to non‐oncogenic conditions. For instance, genetic variants within BBOX1‐AS1 have been associated with an increased risk of myopia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and in premature ovarian failure, BBOX1‐AS1 has been shown to promote granulosa cell apoptosis via sponging miR‑146b."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings elucidate that BBOX1‐AS1 acts as an oncogenic long non‐coding RNA by modulating diverse microRNA‐mediated networks and their downstream effectors, thus promoting cell proliferation, migration, invasion, and survival across multiple cancer types. Its integral function in tumor progression and association with adverse clinical parameters underscore the potential of BBOX1‐AS1 as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Xu, Baohua Yang, Lifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BBOX1-AS1 upregulates HOXC6 expression through miR-361-3p and HuR to drive cervical cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12823"}], "href": "https://doi.org/10.1111/cpr.12823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32515533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32515533"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiang Shi, Chao Yang, Jinlu An, et al. 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