BCAS1 Gene

Name	breast carcinoma amplified sequence 1
Description	This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Breast Carcinoma Amplified Sequence 1 (BCAS1) is a multifunctional protein originally identified in amplified regions of breast cancer that now appears to play diverse roles in both oncogenesis and neural function. In multiple breast cancer studies, BCAS1 is frequently overexpressed and even mutated, with increased levels correlating with features of aggressive tumor phenotypes, tamoxifen resistance, and cancer stem cell behavior; its expression is modulated by epigenetic drugs such as BET bromodomain inhibitors, and it has been implicated in estrogen‐related pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond breast cancer, BCAS1 alterations have been detected in other malignancies. In colorectal cancer, for instance, frequent mutations in BCAS1 have been associated with resistance to cetuximab therapy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while high‐level amplifications involving BCAS1 have been reported in gastroesophageal junction and pancreatic adenocarcinomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "; furthermore, BCAS1 has emerged as a potential biomarker in bladder cancer diagnostic panels"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and appears integrated within cell cycle‐related protein interaction networks in colorectal tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel to its oncogenic implications, BCAS1 is also expressed in the central nervous system. It is localized specifically to oligodendrocytes and Schwann cells and functions as a novel myelin‐associated protein. Loss or reduction of BCAS1 has been linked to hypomyelination, upregulation of inflammation‐related genes, and behavioral abnormalities—including schizophrenia‐like features—underscoring its importance in myelin maintenance and normal neural function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that BCAS1 plays a dual role, contributing to tumorigenic processes in several cancer types as well as to myelin integrity and neural homeostasis. Its modulation by various treatments, its association with estrogen signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", and its inclusion in networks related to cell proliferation further emphasize the potential of BCAS1 as both a diagnostic marker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "James K Burmester, Brian K Suarez, Jennifer H Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of candidate genes for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Hered (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000081443"}], "href": "https://doi.org/10.1159/000081443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15583422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15583422"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ingvild S Fenne, Thomas Helland, Marianne H Flågeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0070096"}], "href": "https://doi.org/10.1371/journal.pone.0070096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23936147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23936147"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Montserrat Pérez-Salvia, Laia Simó-Riudalbas, Pere Llinàs-Arias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.18255"}], "href": "https://doi.org/10.18632/oncotarget.18255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28881673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28881673"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Federica Sotgia, Marco Fiorillo, Michael P Lisanti "}, {"type": "b", "children": [{"type": "t", "text": "Hallmarks of the cancer cell of origin: Comparisons with \"energetic\" cancer stem cells (e-CSCs)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101822"}], "href": "https://doi.org/10.18632/aging.101822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30760648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30760648"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "R G Correa, A F de Carvalho, N A Pinheiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/geno.2000.6172"}], "href": "https://doi.org/10.1006/geno.2000.6172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10857754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10857754"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dillon I Beardsley, David Kowbel, Tamara A Lataxes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-4827(03)00353-7"}], "href": "https://doi.org/10.1016/s0014-4827(03"}, {"type": "t", "text": "00353-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14567997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14567997"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michael Becker, Anette Sommer, Jörn R Krätzschmar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15657362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15657362"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Changwen Jing, Ting Wang, Rong Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23172"}], "href": "https://doi.org/10.1002/mc.23172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32141150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32141150"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Herman van Dekken, Kees Vissers, Hugo W Tilanus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic array and expression analysis of frequent high-level amplifications in adenocarcinomas of the gastro-esophageal junction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2005.11.002"}], "href": "https://doi.org/10.1016/j.cancergencyto.2005.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16631473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16631473"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Panayiotis Loukopoulos, Tatsuhiro Shibata, Hiroto Katoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2007.00395.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2007.00395.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17233815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17233815"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Valentina Casadio, Daniele Calistri, Michela Tebaldi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urine cell-free DNA integrity as a marker for early bladder cancer diagnosis: preliminary data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urolonc.2012.07.013"}], "href": "https://doi.org/10.1016/j.urolonc.2012.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23141783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23141783"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaofeng Cui, Kexin Shen, Zhongshi Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key genes in colorectal cancer using random walk with restart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.6058"}], "href": "https://doi.org/10.3892/mmr.2016.6058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28000901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28000901"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tetsuya Ishimoto, Kensuke Ninomiya, Ran Inoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.23129"}], "href": "https://doi.org/10.1002/glia.23129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28230289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28230289"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J B Lauridsen, J L Johansen, J C Rekling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neures.2011.03.011"}], "href": "https://doi.org/10.1016/j.neures.2011.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21514331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21514331"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "L J Martin, J Blangero, J Rogers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.2001.5.2.75"}], "href": "https://doi.org/10.1152/physiolgenomics.2001.5.2.75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11242591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11242591"}]}]}]}
Synonyms	NABC1, AIBC1
Proteins	BCAS1_HUMAN
NCBI Gene ID	8537
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BCAS1 has 6,095 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for BCAS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BCAS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCAS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCAS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BCAS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BCAS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BCAS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCAS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BCAS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BCAS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BCAS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of BCAS1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BCAS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BCAS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BCAS1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with BCAS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BCAS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BCAS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BCAS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of BCAS1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BCAS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BCAS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BCAS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BCAS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BCAS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BCAS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BCAS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with BCAS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with BCAS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BCAS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BCAS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BCAS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BCAS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BCAS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BCAS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BCAS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BCAS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BCAS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BCAS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with BCAS1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with BCAS1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of BCAS1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.