{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BHLHE40‑AS1 is a long noncoding RNA that appears to play a pivotal role in cancer progression. In breast cancer, particularly in ductal carcinoma in situ (DCIS), increasing expression of BHLHE40‑AS1 is associated with enhanced cell proliferation, motility, and invasion, thereby facilitating the transition to invasive ductal carcinoma. Mechanistically, BHLHE40‑AS1 modulates interleukin‑6/signal transducer and activator of transcription 3 (STAT3) signaling through interactions with factors such as interleukin enhancer‑binding factor 3, which promotes a proinflammatory and immune‑permissive microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in papillary thyroid carcinoma, BHLHE40‑AS1 has been incorporated into an m6A‑related long noncoding RNA prognostic model, where its expression correlates with immune checkpoint expression (e.g., PD‑L1), tumor microenvironment characteristics, and various clinicopathological features, thereby serving as a useful prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Broader analyses of lncRNA‑associated protein–protein interaction modules and germline genetic markers in different cancers underscore the importance of antisense lncRNAs, including BHLHE40‑AS1, in modulating complex gene expression networks and influencing diverse molecular mechanisms underlying cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rebecca S DeVaux, Ali S Ropri, Sandra L Grimm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA BHLHE40-AS1 promotes early breast cancer progression through modulating IL-6/STAT3 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29621"}], "href": "https://doi.org/10.1002/jcb.29621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31907974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31907974"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yinde Huang, Xin Li, Wenbin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the prognostic significance and potential mechanisms of lncRNAs associated with m6A methylation in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.108286"}], "href": "https://doi.org/10.1016/j.intimp.2021.108286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34735975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34735975"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chih-Hsun Wu, Chia-Lang Hsu, Pei-Chun Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep35939"}], "href": "https://doi.org/10.1038/srep35939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27786280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27786280"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hongji Dai, Xinlei Chu, Qian Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Discov (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41421-021-00342-6"}], "href": "https://doi.org/10.1038/s41421-021-00342-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34930913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34930913"}]}]}]}