{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BICC1 encodes an RNA‐binding protein whose diverse functions span developmental regulation, post‐transcriptional control, and disease pathogenesis. In cholangiocarcinoma, BICC1 is notably involved as a fusion partner with FGFR2, generating oncogenic fusion proteins that activate MAPK signaling and promote tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the kidney, BICC1 is critical for proper epithelial function; it normally acts to block canonical Wnt signaling and facilitates miRNA‐mediated repression of transcripts (such as adenylate cyclase‐6 and protein kinase inhibitor α) to maintain normal tubule structure. Loss or mutation of BICC1, or defective interactions with partners such as ANKS6 and SamCystin, leads to cyst formation and polycystic kidney disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n During development, BICC1 is a downstream target of transcription factors such as serum-response factor (SRF) and plays a role in mesoderm and osteoblast differentiation, thereby contributing to cardiovascular formation and bone mineral density regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In the context of cancer, aberrant expression of BICC1 has been documented; for instance, increased BICC1 levels are associated with enhanced cell viability in oral and gastric cancers, correlating with poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, BICC1 has been implicated in neuropsychiatric disorders. Elevated BICC1 messenger RNA levels in key brain regions are linked to depressive behavior, while specific genetic variants appear to modulate hippocampal structure and may offer protection against major depressive disorder. In addition, rapid-acting antidepressants such as ketamine can downregulate BICC1 expression, suggesting its functional involvement in mood regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in development and disease, BICC1 functions in the regulation of mRNA translation. It cooperates with centrosomal components like OFD1 and is recruited by TRIM29 to enhance the translation of specific transcripts (for example, VEZF1 mRNA) in ovarian cancer, highlighting its importance in post‐transcriptional gene regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging genetic studies have linked variants near BICC1 with high myopia, while its evolutionary conservation is underscored by its incorporation into the germline-restricted chromosome in songbirds, suggesting roles in ocular development and other fundamental biological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasuhito Arai, Yasushi Totoki, Fumie Hosoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26890"}], "href": "https://doi.org/10.1002/hep.26890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24122810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24122810"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cormac M Kinsella, Francisco J Ruiz-Ruano, Anne-Marie Dion-Côté, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Programmed DNA elimination of germline development genes in songbirds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-13427-4"}], "href": "https://doi.org/10.1038/s41467-019-13427-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31784533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31784533"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marine R-C Kraus, Séverine Clauin, Yvan Pfister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21610"}], "href": "https://doi.org/10.1002/humu.21610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21922595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21922595"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nathalie Piazzon, Charlotte Maisonneuve, Isabelle Guilleret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjs027"}], "href": "https://doi.org/10.1093/jmcb/mjs027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22641646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22641646"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zeineb Bakey, Marie-Thérèse Bihoreau, Rémi Piedagnel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2015.122"}], "href": "https://doi.org/10.1038/ki.2015.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26039630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26039630"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Emily E Stagner, Denise J Bouvrette, Jianlin Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The polycystic kidney disease-related proteins Bicc1 and SamCystin interact."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.03.113"}], "href": "https://doi.org/10.1016/j.bbrc.2009.03.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19324013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19324013"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Larry D Mesner, Brianne Ray, Yi-Hsiang Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI73072"}], "href": "https://doi.org/10.1172/JCI73072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24789909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24789909"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shu Xing Zhang, Eduardo Garcia-Gras, Diane R Wycuff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413793200"}], "href": "https://doi.org/10.1074/jbc.M413793200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15699019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15699019"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hong Wang, Ying Guo, Nu Mi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by targeting BICC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101567"}], "href": "https://doi.org/10.1016/j.mcp.2020.101567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32259627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32259627"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rulin Zhao, Chao Peng, Conghua Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106828"}], "href": "https://doi.org/10.1016/j.intimp.2020.106828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32736193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32736193"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kristie T Ota, Wells Andres, David A Lewis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/npp.2014.227"}], "href": "https://doi.org/10.1038/npp.2014.227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25178406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25178406"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rachel Bermingham, Angela Carballedo, Danuta Lisiecka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variant in BICC1 on functional and structural brain changes in depression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/npp.2012.158"}], "href": "https://doi.org/10.1038/npp.2012.158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22910460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22910460"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Joanne Ryan, Sylvaine Artero, Isabelle Carrière, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neuropsychopharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.euroneuro.2015.08.022"}], "href": "https://doi.org/10.1016/j.euroneuro.2015.08.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26391493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26391493"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mengxin Shen, Dan Lv, Xu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Bull (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainresbull.2018.10.004"}], "href": "https://doi.org/10.1016/j.brainresbull.2018.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30316917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30316917"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daniela Iaconis, Maria Monti, Mario Renda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-01156-x"}], "href": "https://doi.org/10.1038/s41598-017-01156-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28450740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28450740"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Huai-Yu Qiao, Qi Zhang, Jia-Mei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.12.029"}], "href": "https://doi.org/10.1016/j.canlet.2021.12.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34973391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34973391"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Milly S Tedja, Annechien E G Haarman, Magda A Meester-Smoor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMI - Myopia Genetics Report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.18-25965"}], "href": "https://doi.org/10.1167/iovs.18-25965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30817828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30817828"}]}]}]}