{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BICRAL refers to a set of subunits found within a specialized, non‐canonical form of the mammalian SWI/SNF (BAF) chromatin remodeling complex. These subunits—represented by the mammalian GLTSCR1 and GLTSCR1L proteins—are integral to the formation of what is often termed the GBAF or ncBAF complex. In embryonic stem cells, this complex is selectively targeted to key regulatory regions that drive the expression of genes essential for the maintenance of naive pluripotency, thereby ensuring proper stem cell identity and developmental potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oncogenic contexts, particularly in cancers such as synovial sarcoma and certain leukemias, the incorporation of BICRAL-associated factors into aberrant BAF complexes underlies the activation and maintenance of oncogenic transcriptional programs, rendering these complexes attractive therapeutic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, studies in Drosophila demonstrate that the sole ortholog of these mammalian components—Bicra—is critically involved in neural functions such as courtship learning and decision making, suggesting that BICRAL-containing complexes may also support complex cognitive and behavioral processes across species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these findings indicate that BICRAL subunits play a conserved role in chromatin remodeling by directing context-specific gene regulation in development and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jovylyn Gatchalian, Shivani Malik, Josephine Ho, et al. 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