| HGNC Family | Baculoviral IAP repeat containing (BIRC) |
| Name | baculoviral IAP repeat containing 8 |
| Description | Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nBIRC8, also known as ILP2, is a member of the inhibitor of apoptosis (IAP) family that plays a modulatory role in cell death regulation. In endothelial cells, exposure to steady laminar shear stress leads to a dose‐ and time‐dependent transcriptional induction of HIAP‐2—a homolog of BIRC8—resulting in the suppression of caspase‐3 activity and reduced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, studies in the testis reveal that ILP2 possesses a caspase‐9 inhibitory domain that is intrinsically unstable and only weakly active, implying that its anti‐apoptotic function in vivo may require additional cellular factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatoma (HepG2) cells, exposure to the mycotoxin fumonisin B1 induces a dose‐dependent increase in BIRC8/ILP2 mRNA and protein expression. This upregulation is accompanied by a decrease in the levels of pro‐apoptotic regulators such as Smac/DIABLO, suggesting that BIRC8 may contribute to a complex modulation of the apoptotic pathway under toxic stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in the context of breast cancer, ILP2 has emerged as a novel serological biomarker with functional significance. Elevated ILP2 levels have been detected in breast cancer patient serum and tumor tissues, and functional studies demonstrate that its expression promotes tumor cell viability and migration while suppressing apoptosis. Conversely, knockdown of ILP2 results in reduced cell growth and increased apoptotic cell death, highlighting its potential as both a diagnostic marker and a therapeutic target in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Jin, Masako Mitsumata, Tetsu Yamane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of human inhibitor of apoptosis protein-2 by shear stress in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03361-6"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03361-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12372615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12372615"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hwain Shin, Martin Renatus, Brendan P Eckelman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20041107"}], "href": "https://doi.org/10.1042/BJ20041107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15485395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15485395"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anil A Chuturgoon, Alisa Phulukdaree, Devapregasan Moodley "}, {"type": "b", "children": [{"type": "t", "text": "Fumonisin B₁ inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.toxlet.2015.03.006"}], "href": "https://doi.org/10.1016/j.toxlet.2015.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25800559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25800559"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mingjun Xiang, Wei Zhou, Dandan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms131216737"}], "href": "https://doi.org/10.3390/ijms131216737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23222679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23222679"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lin Zhu, Weihua Zhou, Xidi Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6626"}], "href": "https://doi.org/10.3892/or.2018.6626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106449"}]}]}]}
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| Synonyms | HILP2, ILP-2, RNF136, ILP2 |
| Proteins | BIRC8_HUMAN |
| NCBI Gene ID | 112401 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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BIRC8 has 791 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 42 datasets.
Click the + buttons to view associations for BIRC8 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by BIRC8 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of BIRC8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of BIRC8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of BIRC8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of BIRC8 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of BIRC8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing BIRC8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of BIRC8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with BIRC8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with BIRC8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at BIRC8 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of BIRC8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of BIRC8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with BIRC8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with BIRC8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing BIRC8 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of BIRC8 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of BIRC8 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving BIRC8 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving BIRC8 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing BIRC8 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing BIRC8 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by BIRC8 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by BIRC8 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of BIRC8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of BIRC8 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of BIRC8 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with BIRC8 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for BIRC8 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of BIRC8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of BIRC8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with BIRC8 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of BIRC8 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing BIRC8 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain BIRC8 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for BIRC8 from the Pathway Commons Protein-Protein Interactions dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at BIRC8 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of BIRC8 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of BIRC8 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of BIRC8 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of BIRC8 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with BIRC8 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
