{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA BLACAT1—also known as linc‐UBC1—is frequently upregulated in a broad spectrum of human cancers and plays a critical oncogenic role by modulating diverse cellular processes such as cell cycle regulation, proliferation, migration, invasion, and chemoresistance. BLACAT1 has been shown to promote tumorigenesis through epigenetic mechanisms by physically interacting with chromatin‐modifying proteins (e.g., EZH2) to repress tumor suppressor genes (for example, p15), thereby disrupting normal G1/G0 arrest and facilitating uncontrolled cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, BLACAT1 contributes to chemoresistance in cancers such as gastric and non–small cell lung cancer by acting as a competing endogenous RNA that sponges specific microRNAs—including miR-361, miR-17, miR-144, and those regulating Cyclin D1—thereby upregulating drug resistance–related proteins and autophagy regulators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, BLACAT1 functions as a microRNA “sponge” in several tumor types—including hepatocellular carcinoma, glioma, osteosarcoma, oral squamous cell carcinoma, and cervical carcinoma—where it sequesters microRNAs (such as miR-485-5p, miR-605-3p, miR-142-5p, miR-424, and miR-143) to activate downstream oncogenic pathways (for instance, Wnt/β-catenin, PI3K/AKT, and STAT3 signaling) and thereby enhance malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In line with its multifaceted roles, elevated BLACAT1 expression is consistently associated with adverse clinicopathological features—including advanced tumor stage, lymph node metastasis, and poor overall survival—in a wide range of cancers, as confirmed by meta-analyses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these findings underscore BLACAT1 as both a promising prognostic biomarker and a potential therapeutic target for diverse malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Su, Erbao Zhang, Liang Han, et al. 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