{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BLID, a BH3‐like motif–containing protein also known as a cell death inducer, has emerged as a multifunctional regulator in both ocular disorders and cancer. In pathological myopia, BLID was identified within a novel susceptibility locus at 11q24.1 and shown to be expressed in retinal tissue, suggesting a potential role in eye development and refractive error predisposition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cancer, BLID functions as a proapoptotic tumor suppressor. It interacts with anti‐apoptotic Bcl‐X(L), leading to the activation of Bax and release of cytochrome c, thereby promoting apoptotic cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer, reduced BLID expression is associated with higher tumor grade, triple‐negative status, metastasis, and poorer patient outcomes; its downregulation has been validated as an independent prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, in a pediatric case of B‐cell precursor acute lymphoblastic leukemia, a novel IGH translocation resulted in the concurrent overexpression of BLID and a neighboring microRNA, underscoring the complexity of its regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Conversely, in non–small cell lung cancer and gastric cancer, oncogenic microRNAs such as miR-575 and miR-501 directly suppress BLID, thereby reducing apoptosis and enhancing cell proliferation, invasion, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Notably, genetic association studies in Chinese populations did not replicate the myopia susceptibility findings initially observed in Japanese subjects, suggesting that BLID’s regulatory impact may vary with ethnicity and tissue context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings highlight the critical role of BLID in mediating apoptosis and tumor suppression, as well as its emerging relevance in ocular pathology, thereby offering promising avenues for therapeutic targeting.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hideo Nakanishi, Ryo Yamada, Norimoto Gotoh, et al. 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