{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BMPR1B-AS1 is a long non-coding RNA with emerging relevance in cancer biology. In endometrial carcinoma, BMPR1B-AS1 is upregulated in tumor tissues relative to adjacent non-cancerous tissues and promotes cancer cell proliferation and metastasis. Mechanistically, this lncRNA functions as a competing endogenous RNA by sequestering miR-7-2-3p, thereby modulating the expression of DCLK1 and activating the downstream PI3K/Akt/NF-κB signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, integrated analyses combining gene expression and epigenetic data have identified BMPR1B-AS1 as a potential biomarker for cancer diagnosis, notably in kidney renal clear cell carcinoma, underscoring its diagnostic and possibly prognostic utility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tianjiao Lai, Haifeng Qiu, Lulu Si, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2060003"}], "href": "https://doi.org/10.1080/15384101.2022.2060003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35404759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35404759"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yajie Meng, Min Jin "}, {"type": "b", "children": [{"type": "t", "text": "HFS-SLPEE: A Novel Hierarchical Feature Selection and Second Learning Probability Error Ensemble Model for Precision Cancer Diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.696359"}], "href": "https://doi.org/10.3389/fcell.2021.696359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34277640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34277640"}]}]}]}