BNIP2 Gene

Name	BCL2/adenovirus E1B 19kDa interacting protein 2
Description	This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BNIP2 is a multifunctional protein that acts as a scaffold and signaling adaptor through its highly conserved BNIP‐2 and Cdc42GAP homology (BCH) domain. In muscle and neuronal precursors, BNIP2 couples cell surface receptors (such as Cdo) to intracellular signaling cascades by recruiting regulators of small GTPases (notably Cdc42), thereby promoting p38 mitogen‐activated protein kinase activity and subsequent differentiation (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In this context, BNIP2 not only facilitates cytoskeletal reorganization—inducing cell elongation and membrane protrusions through a unique recruitment of active Cdc42"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "—but also participates in the spatial regulation of signaling complexes by interacting with motor proteins such as KIF5B to ensure proper anterograde intracellular transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in differentiation and cytoskeletal dynamics, BNIP2 is also implicated in the regulation of apoptosis. Its expression is modulated by microRNAs (e.g., miR‐20a), with altered BNIP2 levels being associated with chemotherapeutic drug responses in colorectal adenocarcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, BNIP2 and closely related family members (such as BNIP‐Sα, which possesses a complete BCH domain) exhibit pro‐apoptotic functions. Studies have shown that BNIP2 can be proteolytically processed—either by caspases during apoptosis or by granzyme B in a cytotoxic lymphocyte–mediated context—to generate fragments that further enhance cell death signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, BNIP2 levels have been linked to neuronal cell survival, with modulation by hormonal signals such as estradiol affecting its expression and influencing neuroprotective outcomes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "as well as participating in stress responses regulated by SIRT1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jong-Sun Kang, Gyu-Un Bae, Min-Jeong Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200801119"}], "href": "https://doi.org/10.1083/jcb.200801119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18678706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18678706"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gyu-Un Bae, Jae-Rin Lee, Bok-Geon Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdo interacts with APPL1 and activates Akt in myoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-12-1011"}], "href": "https://doi.org/10.1091/mbc.e09-12-1011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20484574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20484574"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gyu-Un Bae, Bok-Geon Kim, Hye-Jin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00199-09"}], "href": "https://doi.org/10.1128/MCB.00199-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19470755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19470755"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi Ting Zhou, Graeme R Guy, Boon Chuan Low "}, {"type": "b", "children": [{"type": "t", "text": "BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2004.08.044"}], "href": "https://doi.org/10.1016/j.yexcr.2004.08.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15652341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15652341"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peng Yi, Li Li Chew, Ziwang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-03-0797"}], "href": "https://doi.org/10.1091/mbc.E14-03-0797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25378581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25378581"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huijuan Chai, Min Liu, Ruiqing Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmq125"}], "href": "https://doi.org/10.1093/abbs/gmq125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21242194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21242194"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yi Ting Zhou, Unice J K Soh, Xun Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109459200"}], "href": "https://doi.org/10.1074/jbc.M109459200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11741952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11741952"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gina B Scott, Paul A Bowles, Erica B Wilson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20091073"}], "href": "https://doi.org/10.1042/BJ20091073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20704564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20704564"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "S Belcredito, E Vegeto, A Brusadelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Brain Res Rev (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0165-0173(01)00138-2"}], "href": "https://doi.org/10.1016/s0165-0173(01"}, {"type": "t", "text": "00138-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11744098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11744098"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Geunyeong Park, Joo-Won Jeong, Ja-Eun Kim "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.11.048"}], "href": "https://doi.org/10.1016/j.febslet.2010.11.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21130087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21130087"}]}]}]}
Synonyms	BNIP-2, NIP2
Proteins	BNIP2_HUMAN
NCBI Gene ID	663
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BNIP2 has 5,778 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for BNIP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BNIP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BNIP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BNIP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BNIP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BNIP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BNIP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BNIP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BNIP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BNIP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BNIP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BNIP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BNIP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BNIP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with BNIP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BNIP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BNIP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BNIP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BNIP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BNIP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BNIP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing BNIP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing BNIP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BNIP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BNIP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing BNIP2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BNIP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BNIP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BNIP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BNIP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of BNIP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BNIP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BNIP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BNIP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BNIP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BNIP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BNIP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BNIP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BNIP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with BNIP2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with BNIP2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of BNIP2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.