{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators in cancer biology, acting through mechanisms such as competing endogenous RNA (ceRNA) networks and influencing various aspects of tumorigenesis, metastasis, and prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of gastric cancer, one study focusing on ferroptosis‐related lncRNAs identified a signature in which BOLA3‑AS1 was incorporated; here, quantitative RT-PCR analyses confirmed that BOLA3‑AS1 is differentially expressed in gastric cancer cell lines relative to normal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " The observed dysregulation of BOLA3‑AS1 suggests that it may be involved in modulating pathways linked to ferroptosis—a form of regulated cell death that has been implicated in tumor progression—and, as such, it holds potential as a prognostic biomarker. Overall, BOLA3‑AS1 appears to contribute to the complex regulatory network of lncRNAs that govern cancer progression, thereby underlining its possible role in influencing clinical outcomes in gastric cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuang Yang, Qianqian Ning, Guobin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13828"}], "href": "https://doi.org/10.18632/oncotarget.13828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27966444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27966444"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianchao Ying, Qian Wang, Teng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Establishment of a nine-gene prognostic model for predicting overall survival of patients with endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1498"}], "href": "https://doi.org/10.1002/cam4.1498"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29665298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29665298"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianming Wei, Ye Zeng, Xibo Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ferroptosis-related lncRNA signature for prognosis prediction in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08975-2"}], "href": "https://doi.org/10.1186/s12885-021-08975-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34774009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34774009"}]}]}]}