{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated BRD3OS in diverse biological processes, suggesting that it may serve as a multifunctional regulator of gene expression. In a study of smoking‐related lung squamous cell carcinoma, BRD3OS was identified among a panel of biomarkers—including protein‐coding genes, long noncoding RNAs, and transcription factors—that are associated with tumor progression induced by cigarette smoking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other contexts, regulatory complexes that control cell‐specific gene expression appear to involve components with similar modulatory properties as BRD3OS. For example, the histone acetyltransferase CSRP2BP acts as a coactivator by interacting with key transcription factors such as serum response factor (SRF), CRP2, and myocardin to drive smooth muscle gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, disruptions affecting CSRP2BP expression in mouse models result in ocular abnormalities consistent with corneal developmental defects, underscoring a role for transcriptional co-regulators in tissue development and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence from studies investigating fibrogenesis in ovarian endometrioma indicates that TGF-β–driven pathways, which cause myofibroblast activation and extracellular matrix deposition, may also include regulatory elements similar to BRD3OS. This association points to a potential role for BRD3OS in modulating fibrotic processes that affect tissue architecture and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shicheng Li, Xiao Sun, Shuncheng Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential protein-coding gene and long noncoding RNA expression in smoking-related lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12510"}], "href": "https://doi.org/10.1111/1759-7714.12510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28949095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28949095"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanlin Ma, Qi Li, Ankang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CSRP2BP histone acetyltransferase drives smooth muscle gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw1227"}], "href": "https://doi.org/10.1093/nar/gkw1227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27940555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27940555"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anna L Shen, Susan A Moran, Edward A Glover, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0157577"}], "href": "https://doi.org/10.1371/journal.pone.0157577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27310661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27310661"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi Gong, Mian Liu, Qianqian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-024-05243-2"}], "href": "https://doi.org/10.1186/s12967-024-05243-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38867256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38867256"}]}]}]}