{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BRE‐AS1 is a long non‐coding RNA that functions as a tumor suppressor in multiple cancer types by modulating key signaling pathways and gene regulatory networks. In prostate carcinoma, BRE‐AS1 is down‐regulated in patient plasma; its overexpression leads to an up‐regulation of miR‐145-5p, which in turn inhibits cancer cell proliferation and promotes apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer, BRE‐AS1 is similarly decreased and exerts its tumor suppressive effects by physically binding to the transcription factor STAT3. This binding reduces STAT3’s interaction with the promoter of NR4A3, leading to increased NR4A3 expression and consequent inhibition of tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In triple‐negative breast cancer, BRE‐AS1 is down‐regulated and functions by sponging premature miR‐21, thereby suppressing its maturation and increasing PTEN expression; these events are associated with reduced cell proliferation and migration as well as enhanced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in bladder cancer, lower levels of BRE‐AS1 correlate with enhanced tumor cell proliferation, while its overexpression inhibits proliferation and promotes apoptosis through repression of STAT3 phosphorylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that BRE‐AS1 suppresses tumor progression by interacting with microRNAs and transcription factors to regulate downstream gene expression, highlighting its potential as a therapeutic target across diverse malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhongjun Chen, Ming Zhen, Jiajie Zhou "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BRE-AS1 interacts with miR-145-5p to regulate cancer cell proliferation and apoptosis in prostate carcinoma and has early diagnostic values."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20182097"}], "href": "https://doi.org/10.1042/BSR20182097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30833361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30833361"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meichun Zhang, Jing Wu, Weinong Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2018.09.013"}], "href": "https://doi.org/10.1016/j.abb.2018.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30227111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30227111"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianchao Gao, Sisi Wang, Zhisheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA BRE-AS1 inhibits the proliferation, migration, and invasion of cancer cells in triple-negative breast cancer and predicts patients' survival by downregulating miR-21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08294-6"}], "href": "https://doi.org/10.1186/s12885-021-08294-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34182945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34182945"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L Zhang, B Liu, Q-H Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BRE-AS1 acts as a tumor suppressor factor in bladder cancer via mediating STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21314"}], "href": "https://doi.org/10.26355/eurrev_202005_21314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495865"}]}]}]}