{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BRME1, also known as C19orf57 (or 4930432K21Rik in mice), has emerged as a critical factor in maintaining genome stability through its role in DNA repair and recombination. In the context of meiotic recombination, BRME1 directly interacts with single‑stranded DNA binding proteins such as BRCA2 and MEILB2/HSF2BP to ensure the proper recruitment of the recombinases RAD51 and DMC1 onto resected DNA double‑strand break sites. Disruption of BRME1 impairs the timely removal of ssDNA‑binding proteins and delays the loading of recombinases, ultimately leading to faulty double‑strand break repair and infertility, as observed in mouse spermatocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its essential role in meiosis, emerging studies have implicated BRME1 in human reproductive and oncogenic contexts. A candidate BRME1 variant has been associated with primary ovarian insufficiency, suggesting that altered BRME1 function might contribute to reproductive disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, gene expression analyses in cancers such as head and neck squamous cell carcinoma and cervical cancer have identified differential expression patterns of BRME1. These findings implicate its involvement in cell cycle regulation and DNA repair pathways that may influence tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, the studies suggest that BRME1 is indispensable for proper meiotic DNA repair and genomic integrity, with potential broader impacts in human fertility and cancer biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kazumasa Takemoto, Naoki Tani, Yuki Takada-Horisawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.107686"}], "href": "https://doi.org/10.1016/j.celrep.2020.107686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32460033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32460033"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Natalia Felipe-Medina, Sandrine Caburet, Fernando Sánchez-Sáez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.56996"}], "href": "https://doi.org/10.7554/eLife.56996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32845237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32845237"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guocai Tian, You Fu, Dahe Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01863-6"}], "href": "https://doi.org/10.1186/s12935-021-01863-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33712015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33712015"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tingting Chen, Shizhou Yang, Junfen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome sequencing profiles of cervical cancer tissues and SiHa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-019-00706-y"}], "href": "https://doi.org/10.1007/s10142-019-00706-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31456134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31456134"}]}]}]}