{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent study of small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the long noncoding RNA BRWD1‐AS1 was identified as one of six genes whose high expression is significantly associated with poorer overall survival. Specifically, BRWD1‐AS1 was found to be upregulated in tumor samples compared with normal lung tissues and, when integrated into a multi‐gene prognostic signature, contributed to a higher risk score that correlates with advanced clinical and T stages. Although the study did not detail the underlying biological mechanisms of BRWD1‐AS1, its inclusion in the risk model suggests that elevated expression of this gene may serve as a useful biomarker for identifying patients with more aggressive disease and for guiding treatment decisions in small cell lung cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shicheng Feng, Xiuxiu Zhang, Xuyu Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Six Novel Prognostic Gene Signatures as Potential Biomarkers in Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207325666220427121619"}], "href": "https://doi.org/10.2174/1386207325666220427121619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35490316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35490316"}]}]}]}