BSN-AS2 Gene

Name BSN antisense RNA 2 (head to head)
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long noncoding RNA BSN‐AS2 exhibits oncogenic properties in diverse malignancies. In spinal osteosarcoma, BSN‐AS2 is markedly upregulated as a result of transcriptional activation by E2F1, thereby enhancing tumor cell proliferation, migration, and invasion while suppressing apoptosis. Mechanistically, BSN‐AS2 functions as a competing endogenous RNA by sponging miR‐654-3p, which in turn modulates the expression of SYTL2 to drive cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in the context of pheochromocytoma, BSN‐AS2 has been identified as a crucial component of a lncRNA/mRNA/miRNA ceRNA network and serves as an independent predictor of overall survival, underscoring its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xianwei Zhou, Jitian Li, Junyan Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA BSN-AS2 induced by E2F1 promotes spinal osteosarcoma progression by targeting miR-654-3p/SYTL2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01205-y"}], "href": "https://doi.org/10.1186/s12935-020-01205-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32351327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32351327"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying-Chun Liang, Yu-Peng Wu, Dong-Ning Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Building a Competing Endogenous RNA Network to Find Potential Long Non-Coding RNA Biomarkers for Pheochromocytoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000496043"}], "href": "https://doi.org/10.1159/000496043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30562748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30562748"}]}]}]}
Synonyms BSN-DT
NCBI Gene ID 100132677
API
Download Associations
Predicted Functions View BSN-AS2's ARCHS4 Predicted Functions.
Co-expressed Genes View BSN-AS2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View BSN-AS2's ARCHS4 Predicted Functions.

Functional Associations

BSN-AS2 has 1,298 functional associations with biological entities spanning 5 categories (molecular profile, organism, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for BSN-AS2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of BSN-AS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of BSN-AS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of BSN-AS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSN-AS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of BSN-AS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of BSN-AS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at BSN-AS2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSN-AS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of BSN-AS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of BSN-AS2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of BSN-AS2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of BSN-AS2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of BSN-AS2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of BSN-AS2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with BSN-AS2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with BSN-AS2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of BSN-AS2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of BSN-AS2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at BSN-AS2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.