| Name | binder of sperm protein homolog 1 |
| Description | Predicted to enable heparin binding activity. Predicted to be involved in sperm capacitation. Predicted to be located in extracellular region. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Binder of Sperm Protein Homolog 1 (BSPH1) is a member of the BSP protein family that is expressed exclusively in the epididymis of mammals, including humans and rodents (8). Its structure is defined by a pair of fibronectin type‐II (Fn2) domains that mediate binding to several ligands such as phosphatidylcholine‐containing liposomes, low‐density lipoproteins, gelatin, and heparin (1,2,8). These binding activities are thought to underlie BSPH1’s role in remodeling the sperm membrane during maturation and capacitation. In vitro studies, using recombinant BSPH1, have demonstrated that although the protein has no apparent effect on sperm acrosome reaction or intrinsic motility parameters, it efficiently promotes capacitation—a key process required for fertilization (2,3). Moreover, experiments in murine systems indicate that BSPH1 is involved in sperm–egg interactions, where its immuno‐neutralization leads to altered sperm motility and a significant inhibition of fertilization in a dose-dependent manner, suggesting a potential role as a biomarker of sperm fertility and as a candidate target for contraceptive development (6,7). Comparisons with other BSP family members further support that BSPH1 plays a distinct role in promoting capacitation—particularly through interactions with high-density lipoproteins—while non-redundant functions are evident when contrasted with related proteins such as BSPH2 (3,4,7,8). Collectively, these findings establish BSPH1 as an essential mediator in the epididymal maturation of sperm, facilitating membrane modifications that are critical for acquiring fertilization competence."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jasmine Lefebvre, Guy Boileau, Puttaswamy Manjunath "}, {"type": "b", "children": [{"type": "t", "text": "Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gan077"}], "href": "https://doi.org/10.1093/molehr/gan077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19091820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19091820"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "G Plante, I Thérien, C Lachance, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein in capacitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gau006"}], "href": "https://doi.org/10.1093/molehr/gau006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24435510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24435510"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Geneviève Plante, Isabelle Thérien, Puttaswamy Manjunath "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of recombinant murine binder of sperm protein homolog 1 and its role in capacitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.111.096644"}], "href": "https://doi.org/10.1095/biolreprod.111.096644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22539676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22539676"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Geneviève Plante, Jinjiang Fan, Puttaswamy Manjunath "}, {"type": "b", "children": [{"type": "t", "text": "Murine Binder of SPerm homolog 2 (BSPH2): the black sheep of the BSP superfamily."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.113.114272"}], "href": "https://doi.org/10.1095/biolreprod.113.114272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24307707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24307707"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marzieh Eskandari-Shahraki, Bruno Prud'homme, Puttaswamy Manjunath "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR-Cas9-mediated mutation revealed BSPH2 protein is dispensable for male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.23039"}], "href": "https://doi.org/10.1002/mrd.23039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29969530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29969530"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hamed Heidari-Vala, Samin Sabouhi-Zarafshan, Bruno Prud'homme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse sperm-egg interaction and fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.03.127"}], "href": "https://doi.org/10.1016/j.bbrc.2020.03.127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32253033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32253033"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Geneviève Plante, Puttaswamy Manjunath "}, {"type": "b", "children": [{"type": "t", "text": "Murine binder of sperm protein homolog 1: a new player in HDL-induced capacitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-14-0559"}], "href": "https://doi.org/10.1530/REP-14-0559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25602034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25602034"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J Lefebvre, J Fan, S Chevalier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic structure and tissue-specific expression of human and mouse genes encoding homologues of the major bovine seminal plasma proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gal098"}], "href": "https://doi.org/10.1093/molehr/gal098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17085770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17085770"}]}]}]}
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| Synonyms | ELSPBP2 |
| Proteins | BSPH1_HUMAN |
| NCBI Gene ID | 100131137 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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BSPH1 has 998 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 48 datasets.
Click the + buttons to view associations for BSPH1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of BSPH1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of BSPH1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of BSPH1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSPH1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of BSPH1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of BSPH1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of BSPH1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing BSPH1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing BSPH1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with BSPH1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with BSPH1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of BSPH1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with BSPH1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with BSPH1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by BSPH1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with BSPH1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with BSPH1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with BSPH1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at BSPH1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSPH1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of BSPH1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with BSPH1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of BSPH1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving BSPH1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing BSPH1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by BSPH1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of BSPH1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with BSPH1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with BSPH1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of BSPH1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for BSPH1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of BSPH1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of BSPH1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of BSPH1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of BSPH1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of BSPH1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at BSPH1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of BSPH1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of BSPH1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of BSPH1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of BSPH1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of BSPH1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of BSPH1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of BSPH1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of BSPH1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of BSPH1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with BSPH1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with BSPH1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
