{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>BTBD9‐AS1 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n BTBD9‐AS1 is a long non‐coding antisense RNA that, based on emerging evidence, appears to play a regulatory role within neural pathways that govern motor and sleep-related functions. Although the genome-wide association study examining device-based physical activity and sleep duration in over 91,000 UK Biobank participants"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not explicitly mention BTBD9‐AS1, the identification of novel loci in this study supports a broader genetic architecture wherein non-coding transcripts such as BTBD9‐AS1 may modulate gene expression underlying physical activity and sleep phenotypes. In particular, BTBD9‐AS1 may influence the regulation of its sense counterpart, BTBD9, which has been implicated in neural control mechanisms and conditions like restless legs syndrome. These observations suggest that BTBD9‐AS1 might contribute to the molecular underpinnings of physical activity levels and sleep regulation, and consequently, its dysregulation could be a factor in diseases where these traits serve as risk factors. Further research is needed to delineate the specific mechanisms and pathways through which BTBD9‐AS1 exerts its effects on both motor function and sleep duration.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aiden Doherty, Karl Smith-Byrne, Teresa Ferreira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWAS identifies 14 loci for device-measured physical activity and sleep duration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07743-4"}], "href": "https://doi.org/10.1038/s41467-018-07743-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30531941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30531941"}]}]}]}