BTRC Gene

HGNC Family	F-boxes (FBX), WD repeat domain containing (WDR)
Name	beta-transducin repeat containing E3 ubiquitin protein ligase
Description	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BTRC (β‐transducin repeat–containing protein) is the substrate recognition subunit of the SCF (Skp1–Cullin–F‐box) E3 ubiquitin ligase complex that plays a critical role in linking phosphorylation‐dependent signaling to regulated protein degradation. Upon the phosphorylation of specific “phosphodegron” motifs by various upstream kinases (such as GSK3β, CK1, Lats, or S6K1), BTRC binds to target proteins and directs their ubiquitination and subsequent proteasomal degradation. For example, in the regulation of epithelial‐mesenchymal transition (EMT), GSK3β‐mediated phosphorylation of the transcription factor Snail creates a binding site for BTRC, leading to its degradation and thereby limiting EMT (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in the Hippo and Wnt pathways, sequential phosphorylation events mark YAP and TAZ for BTRC binding, which restrains their oncogenic activities by promoting their degradation (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Furthermore, in a Keap1‐independent pathway, phosphorylation of the Neh6 domain of Nrf2 stimulates its association with BTRC, ensuring its degradation and fine‐tuning of antioxidant responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while the degradation of the translation inhibitor PDCD4 is also mediated by BTRC following phosphorylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Structural studies have revealed that BTRC specifically recognizes doubly phosphorylated degron motifs—as seen for β‐catenin—ensuring substrate specificity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the context of developmental and signaling pathways, BTRC mediates the degradation of key transcription factors such as Gli2 in the Sonic hedgehog cascade"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and regulates apoptotic thresholds by targeting the pro‐survival protein Mcl‐1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, BTRC also ensures proper cell cycle progression by degrading regulators such as Wee1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", PER2—a key circadian protein"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "and Cdc25A in response to DNA damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In addition, the proper timing of mitotic events is underscored by studies in which the loss of BTRC (β‐Trcp1) in mouse models results in the stabilization of substrates such as Emi1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n BTRC’s role extends to host–virus interactions as well. The HIV‐1 accessory protein Vpu recruits BTRC to target the antiviral factor BST‐2 for degradation, thereby enhancing viral release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In another instance, phosphorylation‐dependent recruitment of BTRC underlies the degradation of PD-L1 in cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that BTRC is a pivotal mediator in diverse signaling pathways. By recognizing phosphorylated degrons on a wide range of substrates—from transcription factors involved in EMT and developmental pathways to cell cycle regulators and even viral restriction factors—BTRC orchestrates their timely degradation. This regulatory mechanism ensures proper control of cell proliferation, differentiation, apoptosis, circadian rhythm, and immune responses, highlighting BTRC’s central role in maintaining cellular homeostasis and its potential as a therapeutic target in diseases such as cancer and viral infections.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Binhua P Zhou, Jiong Deng, Weiya Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1173"}], "href": "https://doi.org/10.1038/ncb1173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15448698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15448698"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jong In Yook, Xiao-Yan Li, Ichiro Ota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt-dependent regulation of the E-cadherin repressor snail."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413878200"}], "href": "https://doi.org/10.1074/jbc.M413878200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15647282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15647282"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bin Zhao, Li Li, Karen Tumaneng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1843810"}], "href": "https://doi.org/10.1101/gad.1843810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20048001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20048001"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chen-Ying Liu, Zheng-Yu Zha, Xin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.152942"}], "href": "https://doi.org/10.1074/jbc.M110.152942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20858893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20858893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Luca Azzolin, Francesca Zanconato, Silvia Bresolin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of TAZ as mediator of Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.11.027"}], "href": "https://doi.org/10.1016/j.cell.2012.11.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23245942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23245942"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Patricia Rada, Ana I Rojo, Sudhir Chowdhry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01204-10"}], "href": "https://doi.org/10.1128/MCB.01204-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21245377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21245377"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "N Valerio Dorrello, Angelo Peschiaroli, Daniele Guardavaccaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1130276"}], "href": "https://doi.org/10.1126/science.1130276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17053147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17053147"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Geng Wu, Guozhou Xu, Brenda A Schulman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00234-x"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00234-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12820959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12820959"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong Pan, Chunyang Brian Bai, Alexandra L Joyner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.9.3365-3377.2006"}], "href": "https://doi.org/10.1128/MCB.26.9.3365-3377.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16611981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16611981"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qingqing Ding, Xianghuo He, Jung-Mao Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00620-06"}], "href": "https://doi.org/10.1128/MCB.00620-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17387146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17387146"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0307700101"}], "href": "https://doi.org/10.1073/pnas.0307700101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15070733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15070733"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Erik J Eide, Margaret F Woolf, Heeseog Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.7.2795-2807.2005"}], "href": "https://doi.org/10.1128/MCB.25.7.2795-2807.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15767683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15767683"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Luca Busino, Maddalena Donzelli, Massimo Chiesa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02082"}], "href": "https://doi.org/10.1038/nature02082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14603323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14603323"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Daniele Guardavaccaro, Yasusei Kudo, Jérôme Boulaire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1534-5807(03)00154-0"}], "href": "https://doi.org/10.1016/s1534-5807(03"}, {"type": "t", "text": "00154-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12791266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12791266"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Janet L Douglas, Kasinath Viswanathan, Matthew N McCarroll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00242-09"}], "href": "https://doi.org/10.1128/JVI.00242-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19515779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19515779"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Richard S Mitchell, Chris Katsura, Mark A Skasko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1000450"}], "href": "https://doi.org/10.1371/journal.ppat.1000450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19478868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19478868"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chia-Wei Li, Seung-Oe Lim, Weiya Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12632"}], "href": "https://doi.org/10.1038/ncomms12632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27572267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27572267"}]}]}]}
Synonyms	FWD1, FBW1A, BETA-TRCP, FBXW1, BTRCP1, FBXW1A, BETATRCP, BTRCP
Proteins	FBW1A_HUMAN
NCBI Gene ID	8945
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BTRC has 8,555 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for BTRC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BTRC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BTRC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BTRC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BTRC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BTRC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BTRC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BTRC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving BTRC protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BTRC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BTRC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of BTRC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BTRC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BTRC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with BTRC gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BTRC protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BTRC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BTRC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BTRC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing BTRC protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BTRC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BTRC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BTRC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing BTRC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BTRC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BTRC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing BTRC protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BTRC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with BTRC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with BTRC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BTRC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with BTRC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BTRC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BTRC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BTRC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BTRC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BTRC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BTRC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BTRC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BTRC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BTRC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with BTRC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.