{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Blood vessel epicardial substance antisense RNA 1 (BVES‐AS1) is emerging as a tumor‐suppressive long noncoding RNA with multifaceted functions in cancer. In colon adenocarcinoma, BVES‐AS1 is expressed at low levels, and its overexpression inhibits cancer cell proliferation, migration, invasion, and epithelial–mesenchymal transition while promoting apoptosis. Mechanistically, BVES‐AS1 functions as a competing endogenous RNA that sponges miR‑522‑3p, thereby modulating the expression of its nearby gene BVES. In addition, BVES‐AS1 recruits TAF15 to enhance the stability of BVES mRNA, collectively contributing to the suppression of tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in colon adenocarcinoma, BVES‐AS1 is also incorporated within prognostic panels. In triple‐negative breast cancer, for example, it contributes to a signature of m6A‑related long noncoding RNAs that predict overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, co‐regulatory analyses in colon cancer have identified BVES‑AS1 as part of a network with other lncRNAs—such as MYLK‑AS1—that may serve as valuable prognostic markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings implicate BVES‑AS1 as a multifunctional regulator with potential clinical utility both as a therapeutic target and as a biomarker for cancer prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wu Wen, Haiyan Wang, Shuang Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BVES-AS1 inhibits the malignant behaviors of colon adenocarcinoma cells via regulating BVES."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11634"}], "href": "https://doi.org/10.1002/cbin.11634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34003551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34003551"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Wu, Yan Cai, Gaiping Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ten N6-methyladenosine-related long non-coding RNAs signature predicts prognosis of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23779"}], "href": "https://doi.org/10.1002/jcla.23779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33934391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33934391"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanwei Xing, Zhiwei Zhao, Yuekun Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of differential expression profiles of mRNAs and lncRNAs and identification of a 14-lncRNA prognostic signature for patients with colon adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6324"}], "href": "https://doi.org/10.3892/or.2018.6324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29565464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29565464"}]}]}]}