{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, RPARP‐AS1 functions as an oncogenic long noncoding RNA that promotes tumor cell proliferation and survival by modulating lipid metabolism. Specifically, its expression enhances the levels of key lipogenic enzymes including FABP4, MAGL, and SCD1, which in turn alters the cellular balance of free fatty acids and triglycerides. These metabolic changes appear to engage the Akt/mTOR signaling pathway and influence both epithelial‐mesenchymal transition and apoptosis, thereby contributing to tumor progression and an aggressive clinical phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Cai, Luhua Liu, Yuan Bo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RPARP-AS1 promotes the progression of osteosarcoma cells through regulating lipid metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-024-11901-x"}], "href": "https://doi.org/10.1186/s12885-024-11901-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38308235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38308235"}]}]}]}