{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The current collection of studies highlights the power of large‐scale, high‐throughput approaches to identify and begin characterizing genes that have not yet been functionally defined. In this context, C11orf71 appears as one of several “previously uncharacterized” genes emerging from such genome‐wide screens. Although none of the provided abstracts specifically detail a molecular or physiological role for C11orf71, one study that generated an arrayed lentiviral expression library noted that some clones corresponding to uncharacterized proteins produced very low viral titers and caused cytotoxicity in HEK293T cells (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This observation hints that C11orf71, if it is among these proteins, might influence cell viability or related cellular processes when overexpressed."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In other reports, comprehensive gene expression profiling in varied disease contexts—ranging from cerebral vessel pathology induced by hypertension or hypercholesterolemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", to asthma and allergy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", to spermatogenesis and male infertility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", as well as investigations into coronary artery disease"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and COVID‐19 severity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "—serve to underscore the complexity of disease‐associated gene networks. Although C11orf71 is not specifically spotlighted in these studies, its occurrence within collections of uncharacterized open reading frames suggests that it may be one of several genes whose functions are “in waiting” to be explored."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while the exact function of C11orf71 remains to be elucidated, the cited works collectively emphasize that systematic, unbiased screens are identifying such genes as potential modulators in diverse biological contexts. Future investigations are needed to clarify whether C11orf71 may influence cellular processes such as viability or contribute to the pathogenesis of complex human diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dubravka Škalamera, Mareike Dahmer, Amy S Purdon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of human ORFs and identification of human genes affecting viral titer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0051733"}], "href": "https://doi.org/10.1371/journal.pone.0051733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23251614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23251614"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Yi Ong, Mary Pei-Ern Ng, Sau-Yeen Loke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive gene expression profiling reveals synergistic functional networks in cerebral vessels after hypertension or hypercholesterolemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0068335"}], "href": "https://doi.org/10.1371/journal.pone.0068335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23874591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23874591"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael E March, Patrick Ma Sleiman, Hakon Hakonarson "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms and associated susceptibility to asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S28156"}], "href": "https://doi.org/10.2147/IJGM.S28156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23637549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23637549"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seyed Morteza Razavi, Marjan Sabbaghian, Mahdi Jalili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive functional enrichment analysis of male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-16005-0"}], "href": "https://doi.org/10.1038/s41598-017-16005-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29150651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29150651"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiao-Lin Ma, Xu Yang, Rui Fan "}, {"type": "b", "children": [{"type": "t", "text": "Screening of miRNA target genes in coronary artery disease by variational Bayesian Gaussian mixture model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2019.7195"}], "href": "https://doi.org/10.3892/etm.2019.7195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30867700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30867700"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuanfeng Li, Yuehua Ke, Xinyi Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of COVID-19 severity among the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Discov (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41421-021-00318-6"}], "href": "https://doi.org/10.1038/s41421-021-00318-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34465742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34465742"}]}]}]}