{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Multiple independent studies have demonstrated that the gene C1orf132 plays a dual role in biomedical research. On one hand, the methylation status of C1orf132 has been robustly associated with chronological age in various tissues—including blood, saliva, and hair—and is therefore frequently incorporated into forensic age‐prediction models. In these studies, its CpG methylation levels consistently correlate with donor age, contributing to multivariate prediction panels that yield high accuracy across different populations and even in complex scenarios such as after hematopoietic stem cell transplantation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": " On the other hand, beyond serving as a robust epigenetic marker of aging, C1orf132 has been implicated in more specific cellular functions. Notably, one investigation found that the CpG sites within C1orf132—whose gene product encodes the microRNA MIR29B2C—exhibit unique methylation dynamics following allogeneic hematopoietic stem cell transplantation; this observation suggests a potential role in regulating the self‐renewal of hematopoietic stem cells and, consequently, graft function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, dysregulation of C1orf132 expression has emerged as part of a prognostic signature in lung adenocarcinoma, further supporting its relevance as a biomarker in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yessenia Anaya, Patrick Yew, Katherine A Roberts, et al. 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