{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA C1QTNF1‐AS1 plays a tumor‐suppressive role in hepatocellular carcinoma (HCC) by modulating the miR-221-3p/SOCS3 axis. In HCC tissues and cell lines, both C1QTNF1‐AS1 and SOCS3 are downregulated, while miR-221-3p is elevated. Experimental overexpression of C1QTNF1‐AS1 leads to a reduction in miR-221-3p levels, thereby relieving repression on SOCS3. The subsequent increase in SOCS3 expression results in inhibition of the JAK/STAT signaling pathway, which reduces cell proliferation, migration, and invasion and promotes apoptosis. These findings, demonstrated in both in vitro cell models and in vivo tumor xenograft studies, underscore the potential of C1QTNF1‐AS1 as a therapeutic target in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary research on miR-221 further supports its oncogenic role in HCC, thereby emphasizing the critical nature of its regulation via multiple molecular axes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, integrative multi-omics analyses in cervical cancer have identified C1QTNF1‐AS1 among a group of long non‐coding RNAs with distinct copy number variations linked to poor prognosis. This finding expands the clinical relevance of C1QTNF1‐AS1 beyond HCC, suggesting it may serve as a valuable prognostic biomarker in other malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hang Li, Bo Zhang, Meng Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C1QTNF1-AS1 regulates the occurrence and development of hepatocellular carcinoma by regulating miR-221-3p/SOCS3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatol Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12072-019-09944-5"}], "href": "https://doi.org/10.1007/s12072-019-09944-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31069760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31069760"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weijie Han, Guofeng Yu, Xianmei Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential of C1QTNF1-AS1 regulation in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03569-w"}], "href": "https://doi.org/10.1007/s11010-019-03569-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31222560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31222560"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20225526"}], "href": "https://doi.org/10.3390/ijms20225526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31698701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31698701"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qihang Zhong, Minzhen Lu, Wanqiong Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-02705-9"}], "href": "https://doi.org/10.1186/s12967-021-02705-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557879"}]}]}]}