{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative studies in cancer‐related long noncoding RNAs have begun to shed light on the functional roles of emerging transcripts such as C1RL‐AS1. While many lncRNAs remain poorly characterized, converging evidence indicates that C1RL‐AS1 may serve as a regulatory hub in tumorigenesis by acting as a competing endogenous RNA (ceRNA) that interacts with multiple cancer‐associated microRNAs and thereby modulates the expression of nearby protein‐coding genes. In one study, a state‐of‐the‐art machine learning classifier (CRlncRC2) was developed to identify cancer‐related lncRNA candidates based on multi‐omics features—including somatic mutation profiles, genomic proximity to known cancer genes, and differential expression in tumor tissues—which supports the candidacy of transcripts like C1RL‐AS1 in influencing oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similar investigations have further implicated lncRNAs in fine‐tuning cellular networks that control cell proliferation, apoptosis, and immune responses within the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these studies suggest that C1RL‐AS1, like other cancer‐related lncRNAs, might contribute to tumor progression and may hold promise both as a biomarker and as a potential therapeutic target. Ongoing and future functional assays will be critical to clarify the precise molecular mechanisms by which C1RL‐AS1 exerts its influence in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuan Zhang, Tianjun Li, Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Cancer-Related Long Non-Coding RNAs Using XGBoost With High Accuracy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00735"}], "href": "https://doi.org/10.3389/fgene.2019.00735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31456817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31456817"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenru Jiang, Yingtao Song, Zhaowei Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ferroptosis-Related Long Non-Coding RNA Signature Contributes to the Prediction of Prognosis Outcomes in Head and Neck Squamous Cell Carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.785839"}], "href": "https://doi.org/10.3389/fgene.2021.785839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34976018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34976018"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wu Zhen-Hua, Gong Yi-Wei, Zhao Li-Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of LncRNA C1RL-AS1 Suppresses the Malignant Phenotype in Gastric Cancer Cells via the AKT/β-Catenin/c-Myc Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.01508"}], "href": "https://doi.org/10.3389/fonc.2020.01508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32983994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32983994"}]}]}]}