{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long noncoding RNA (lncRNA) C20orf166‐AS1 plays roles in cancer biology by participating in several cancer‐related signaling pathways and by serving as a potential diagnostic and prognostic biomarker. In glioblastoma, for example, C20orf166‐AS1 has been identified in a prognostic signature where its expression was associated with antigen processing and presentation as well as cell adhesion molecule pathways, suggesting a function in modulating immune-related processes and cell–cell interactions during tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric adenocarcinoma, C20orf166‐AS1 has been recognized as one of a panel of six lncRNAs with excellent diagnostic value, and network analyses have further implicated it as a key node whose abnormal expression is linked to the MAPK signaling pathway, potentially influencing tumor growth and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, differential expression of C20orf166‐AS1 in prostate cancer tissues has highlighted its potential as a prostate cancer–specific marker, underscoring its emerging relevance across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruqing Liang, Yaqin Zhi, Guizhi Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of long non-coding RNAs in glioblastoma for prognosis prediction using weighted gene co-expression network analysis, Cox regression, and L1-LASSO penalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S171957"}], "href": "https://doi.org/10.2147/OTT.S171957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30613154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30613154"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tao Fu, Xin Ji, Zhaode Bu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key long non-coding RNAs in gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-192389"}], "href": "https://doi.org/10.3233/CBM-192389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32176636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32176636"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Wang, Yanrui Ding, Yanyan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the complex regulatory relationships related to gastric cancer from lncRNA-miRNA-mRNA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29332"}], "href": "https://doi.org/10.1002/jcb.29332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31452262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31452262"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cheng-Cheng Hu, Ping Gan, Rui-Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of prostate cancer LncRNAs by RNA-Seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.21.9439"}], "href": "https://doi.org/10.7314/apjcp.2014.15.21.9439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25422238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25422238"}]}]}]}