C21ORF91-OT1 Gene

Name C21orf91 overlapping transcript 1
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations have revealed a multifaceted role for the long noncoding RNA C21orf91-OT1 in disease mechanisms. In one study on human trabecular meshwork cells under oxidative stress, a competing endogenous RNA (ceRNA) network was constructed to elucidate the potential pathogenic mechanisms in glaucoma. Within this network, C21orf91-OT1, among other dysregulated lncRNAs, is inferred to participate in sequestering specific microRNAs, thereby modulating the expression of target mRNAs under oxidative conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate study focusing on bladder urothelial carcinoma, C21orf91-OT1 was identified as a component of a ten‐lncRNA prognostic signature. This signature robustly stratified patients according to survival outcomes, with its associated biological pathways implicating critical processes such as cell cycle regulation, DNA repair, and immune responses. Thus, C21orf91-OT1 emerges as a potential prognostic biomarker, underscoring its relevance in defining tumor behavior and patient risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke Yao, Yixian Yu, Fei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of an lncRNA‑associated competing endogenous RNA network in human trabecular meshwork cells under oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.10955"}], "href": "https://doi.org/10.3892/mmr.2020.10955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32016457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32016457"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "XuDong Mao, ShiHan Chen, GongHui Li "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a ten-long noncoding RNA signature for predicting the survival and immune status of patients with bladder urothelial carcinoma based on the GEO database: a superior machine learning model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202553"}], "href": "https://doi.org/10.18632/aging.202553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33621953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33621953"}]}]}]}
Synonyms NCRNA00285, D21S2089E, C21orf91-OT1
NCBI Gene ID 246312
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Predicted Functions View C21ORF91-OT1's ARCHS4 Predicted Functions.
Co-expressed Genes View C21ORF91-OT1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View C21ORF91-OT1's ARCHS4 Predicted Functions.

Functional Associations

C21ORF91-OT1 has 586 functional associations with biological entities spanning 5 categories (molecular profile, organism, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for C21ORF91-OT1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of C21ORF91-OT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of C21ORF91-OT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of C21ORF91-OT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at C21ORF91-OT1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of C21ORF91-OT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of C21ORF91-OT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of C21ORF91-OT1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of C21ORF91-OT1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of C21ORF91-OT1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of C21ORF91-OT1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with C21ORF91-OT1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with C21ORF91-OT1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of C21ORF91-OT1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of C21ORF91-OT1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of C21ORF91-OT1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at C21ORF91-OT1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.