{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in adrenocortical carcinoma have revealed that C22orf46P is indirectly up‐regulated through the activity of a novel circular RNA, circ‑CCAC1, which sponges miR‑514a‑5p. This molecular interplay leads to increased C22orf46P expression and is associated with enhanced tumor progression and poor prognosis in ACC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate line of investigation examining gene clusters enriched in the epididymis – including several lipocalin and Ly6 family members – no direct role for C22orf46P was identified in the context of sperm maturation. This observation suggests that the oncogenic functions of C22orf46P are likely to be tissue‐specific rather than universally involved in all processes mediated by regionally enriched genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, functional analyses in non‑small cell lung cancer have characterized C22orf46P, now designated as Tumor Apoptosis Associated Protein 1 (TAAP1), as a nucleolar protein that exhibits remote homology to BH‑domain‐containing members of the Bcl‑2 family. TAAP1/C22orf46P facilitates pro‑survival signaling in tumor cells, rendering them more resistant to CD8+ T‑cell–mediated apoptosis and to the cytotoxic effects of genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Li, Rengong Liu, Dongmei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3501451"}], "href": "https://doi.org/10.1155/2020/3501451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33195693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33195693"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nobuyuki Sakurai, Yoshitaka Fujihara, Kiyonori Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Andrology (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/andr.13350"}], "href": "https://doi.org/10.1111/andr.13350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36428102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36428102"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marietta Döring, Melanie Brux, Maciej Paszkowski-Rogacz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202302257"}], "href": "https://doi.org/10.26508/lsa.202302257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38228372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38228372"}]}]}]}